{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:42:09Z","timestamp":1793191329864,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007234","name":"University of Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) is a major autoimmune disease that causes synovitis and joint damage. Although clinical trials have been performed using interleukin\u201010 (IL\u201010), an antiinflammatory cytokine, as a potential treatment of RA, the therapeutic effects of IL\u201010 have been limited, potentially due to insufficient residence in lymphoid organs, where antigen recognition primarily occurs. This study was undertaken to engineer an IL\u201010\u2013serum albumin (SA) fusion protein and evaluate its effects in 2 murine models of RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SA\u2010fused IL\u201010 (SA\u2013IL\u201010) was recombinantly expressed. Mice with collagen antibody\u2013induced arthritis (n = 4\u20137 per group) or collagen\u2010induced arthritis (n = 9\u201315 per group) were injected intravenously with wild\u2010type IL\u201010 or SA\u2013IL\u201010, and the retention of SA\u2013IL\u201010 in the lymph nodes (LNs), immune cell composition in the paws, and therapeutic effect of SA\u2013IL\u201010 on mice with arthritis were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SA fusion to IL\u201010 led to enhanced accumulation in the mouse LNs compared with unmodified IL\u201010. Intravenous SA\u2013IL\u201010 treatment restored immune cell composition in the paws to a normal status, elevated the frequency of suppressive alternatively activated macrophages, reduced IL\u201017A levels in the paw\u2010draining LN, and protected joint morphology. Intravenous SA\u2013IL\u201010 treatment showed similar efficacy as treatment with an anti\u2013tumor necrosis factor antibody. SA\u2013IL\u201010 was equally effective when administered intravenously, locally, or subcutaneously, which is a benefit for clinical translation of this molecule.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SA fusion to IL\u201010 is a simple but effective engineering strategy for RA therapy and has potential for clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.41585","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T05:22:31Z","timestamp":1604985751000},"page":"769-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin\u201010 in Murine Models"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-2113","authenticated-orcid":false,"given":"Eiji","family":"Yuba","sequence":"first","affiliation":[{"name":"University of Chicago, Chicago, Illinois, and Osaka Prefecture University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Budina","sequence":"additional","affiliation":[{"name":"University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-7892","authenticated-orcid":false,"given":"Kiyomitsu","family":"Katsumata","sequence":"additional","affiliation":[{"name":"University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ako","family":"Ishihara","sequence":"additional","affiliation":[{"name":"University of Chicago  Chicago Illinois 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