{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:35:00Z","timestamp":1787798100154,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K24AR052361"],"award-info":[{"award-number":["K24AR052361"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P50AR060772"],"award-info":[{"award-number":["P50AR060772"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether serum urate reduction with allopurinol lowers blood pressure (BP) in young adults and the mechanisms mediating this hypothesized effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010center, randomized, double\u2010blind, crossover clinical trial. Adults ages 18\u201340 years with baseline systolic BP \u2265120 and &lt;160 mm Hg or diastolic BP \u226580 and &lt;100 mm Hg, and serum urate \u22655.0 mg\/dl for men or \u22654.0 mg\/dl for women were enrolled. Main exclusion criteria included chronic kidney disease, gout, or past use of urate\u2010lowering therapies. Participants received oral allopurinol (300 mg daily) or placebo for 1 month followed by a 2\u20134 week washout and then were crossed over. Study outcome measures were change in systolic BP from baseline, endothelial function estimated as flow\u2010mediated dilation (FMD), and high\u2010sensitivity C\u2010reactive protein (hsCRP) levels. Adverse events were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010nine participants were randomized, and 82 completed all visits. The mean \u00b1 SD age was 28.0 \u00b1 7.0 years, 62.6% were men, and 40.4% were African American. In the primary intent\u2010to\u2010treat analysis, systolic BP did not change during the allopurinol treatment phase (mean \u00b1 SEM \u22121.39 \u00b1 1.16 mm Hg) or placebo treatment phase (\u22121.06 \u00b1 1.08 mm Hg). FMD increased during allopurinol treatment periods compared to placebo treatment periods (mean \u00b1 SEM 2.5 \u00b1 0.55% versus \u22120.1 \u00b1 0.42%; <jats:italic>P<\/jats:italic> &lt; 0.001). There were no changes in hsCRP level and no serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that urate\u2010lowering therapy with allopurinol does not lower systolic BP or hsCRP level in young adults when compared with placebo, despite improvements in FMD. These findings do not support urate lowering as a treatment for hypertension in young adults.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41749","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T02:00:35Z","timestamp":1616983235000},"page":"1514-1522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effect of Serum Urate Lowering With Allopurinol on Blood Pressure in Young Adults: A Randomized, Controlled, Crossover Trial"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7365-7212","authenticated-orcid":false,"given":"Angelo L.","family":"Gaffo","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham and Birmingham VA Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Rahn","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Oparil","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Dudenbostel","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel\u00a0I.","family":"Feig","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Redden","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Muntner","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J.","family":"Foster","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Biggers\u2010Clark","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Mudano","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-6828","authenticated-orcid":false,"given":"Sebastian E.","family":"Sattui","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, and Hospital for Special Surgery  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Saddekni","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3785-1389","authenticated-orcid":false,"suffix":"Jr.","given":"S. 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