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After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising clinicians and patients achieved consensus on the direction (for or against) and strength (strong or conditional) of recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The guideline addresses treatment with disease\u2010modifying antirheumatic drugs (DMARDs), including conventional synthetic DMARDs, biologic DMARDs, and targeted synthetic DMARDs, use of glucocorticoids, and use of DMARDs in certain high\u2010risk populations (i.e., those with liver disease, heart failure, lymphoproliferative disorders, previous serious infections, and nontuberculous mycobacterial lung disease). The guideline includes 44 recommendations (7 strong and 37 conditional).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This clinical practice guideline is intended to serve as a tool to support clinician and patient decision\u2010making. Recommendations are not prescriptive, and individual treatment decisions should be made through a shared decision\u2010making process based on patients\u2019 values, goals, preferences, and comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.41752","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T04:04:51Z","timestamp":1623211491000},"page":"1108-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":778,"title":["2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6148-610X","authenticated-orcid":false,"given":"Liana","family":"Fraenkel","sequence":"first","affiliation":[{"name":"Berkshire Medical Center, Pittsfield, Massachusetts, and Yale University School of Medicine  New Haven Connecticut United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Bathon","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center New York Presbyterian Hospital  New York New York United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-3588","authenticated-orcid":false,"given":"Bryant R.","family":"England","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and VA Nebraska\u2013Western Iowa Health Care System  Omaha Nebraska United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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