{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:56:40Z","timestamp":1790647000098,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Silica is an environmental substance strongly linked with autoimmunity. The aim of this study was to assess the prevalence of antineutrophil cytoplasmic antibody (ANCA)\u2013associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and renal limited vasculitis, in a northeastern region of France and to evaluate whether there was a geospatial association between the localization of quarries in the region and the prevalence of these AAVs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Potential AAV patients were identified using 3 sources: hospital records, immunology laboratories, and the French National Health Insurance System. Patients who resided in the Alsace region of France as of January 1, 2016 and who fulfilled the American College of Rheumatology criteria for GPA or the 2012 Chapel Hill Consensus Conference definitions for GPA or MPA were included. Incomplete case ascertainment was corrected using a capture\u2013recapture analysis. The spatial association between the number of cases and the presence of quarries in each administrative entity was assessed using regression analyses weighted for geographic region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 910 potential AAV patients, we identified 185 patients fulfilling inclusion criteria: 120 patients with GPA, 35 patients with MPA, and 30 patients with renal limited vasculitis. The number of cases missed by any source as estimated by capture\u2013recapture analysis was 6.4 (95% confidence interval [95% CI] 3.6\u201311.5). Accordingly, the estimated prevalence in Alsace in 2016 was 65.5 GPA cases per million inhabitants (95% CI 47.3\u201393.0), 19.1 MPA cases per million inhabitants (95% CI 11.3\u201334.3), and 16.8 renal limited vasculitis cases per million inhabitants (95% CI 8.7\u201335.2). The risk of AAV was significantly increased in communities with quarries (odds ratio 2.51 [95% CI 1.66\u20133.80]), and geographic\u2010weighted regression analyses revealed a significant spatial association between the proximity to quarries and the number of GPA cases (<jats:italic>P<\/jats:italic> = 0.039). In analyses stratifying the AAV patients by ANCA serotype, a significant association between the presence of quarries and positivity for both proteinase 3 ANCAs (<jats:italic>P<\/jats:italic> = 0.04) and myeloperoxidase ANCAs (<jats:italic>P<\/jats:italic> = 0.03) was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a region with a high density of quarries, the spatial association between the presence of and proximity to quarries and the prevalence of AAVs supports the idea that silica may have a role as a specific environmental factor in this disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41767","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T22:47:37Z","timestamp":1619045257000},"page":"2078-2085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence of Antineutrophil Cytoplasmic Antibody\u2013Associated Vasculitis and Spatial Association With Quarries in a Region of Northeastern France: A Capture\u2013Recapture and Geospatial Analysis"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4791-9618","authenticated-orcid":false,"given":"St\u00e9phane","family":"Giorgiutti","sequence":"first","affiliation":[{"name":"Le Centre National de Reference pour les Maladies Autoimmunes Systemiques Rares (CNR RESO) H\u00f4pitaux Universitaires de Strasbourg, and Universit\u00e9 de Strasbourg INSERM UMR S1109  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Dieudonne","sequence":"additional","affiliation":[{"name":"Le Centre National de Reference pour les Maladies Autoimmunes Systemiques Rares (CNR RESO) H\u00f4pitaux Universitaires de Strasbourg, and Universit\u00e9 de Strasbourg INSERM UMR S1109  Strasbourg 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