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RA cases were identified based on self\u2010report and current disease\u2010modifying antirheumatic drug\/glucocorticoid use. Controls were subjects without RA from the general population. Outcome measures included continuous forced expiratory volume in 1 second percent predicted (FEV<jats:sub>1<\/jats:sub>%) and forced vital capacity percent predicted (FVC%), type of spirometric pattern (restrictive or obstructive), and severity of the restrictive or obstructive pattern. We used multivariable regression to estimate the effects in RA cases compared to the effects in controls, adjusting for age, sex, body mass index, and smoking status\/pack\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 350,776 analyzed subjects who underwent spirometry (mean age 56.3 years; 55.8% female; 45.5% ever smokers), we identified 2,008 cases of treated RA. In multivariable analyses, RA was associated with lower FEV<jats:sub>1<\/jats:sub>% (\u03b2 = \u20132.93 [95% confidence interval (95% CI) \u20133.63, \u20132.24]), FVC% (\u03b2 = \u20132.08 [95% CI \u20132.72, \u20131.45]), and FEV<jats:sub>1<\/jats:sub>\/FVC (\u03b2 = \u20130.008 [95% CI \u20130.010, \u20130.005]) compared to controls. RA was additionally associated with restrictive patterns (odds ratio [OR] 1.36 [95% CI 1.21, 1.52]) and obstructive patterns (OR 1.21 [95% CI 1.07, 1.37]) independent of confounders, and was most strongly associated with severe restrictive and obstructive patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RA is associated with increased odds of restrictive and obstructive patterns, and this relationship is not explained by confounders, including smoking status. In addition to restrictive lung disease, clinicians should also be aware that airway obstruction may be a pulmonary manifestation of RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41791","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T08:21:02Z","timestamp":1620894062000},"page":"1994-2002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Relationship Between Rheumatoid Arthritis and Pulmonary Function Measures on Spirometry in the UK Biobank"],"prefix":"10.1002","volume":"73","author":[{"given":"Lauren","family":"Prisco","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Moll","sequence":"additional","affiliation":[{"name":"Harvard Medical School and Brigham and Women\u2019s Hospital  Boston 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