{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:56:35Z","timestamp":1760784995007,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T00:00:00Z","timestamp":1640476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015391","name":"The Myositis Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To define the prevalence and clinical phenotype of anti\u2010cortactin autoantibodies in adult and juvenile myositis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this longitudinal cohort study, anti\u2010cortactin autoantibody titers were assessed by enzyme\u2010linked immunosorbent assay in 670 adult myositis patients and 343 juvenile myositis patients as well as in 202 adult healthy controls and 90 juvenile healthy controls. The prevalence of anti\u2010cortactin autoantibodies was compared among groups. Clinical features of patients with and those without anti\u2010cortactin autoantibodies were also compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010cortactin autoantibodies were more common in adult dermatomyositis (DM) patients (15%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005), particularly those with coexisting anti\u2013Mi\u20102 autoantibodies (24%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) or anti\u2013NXP\u20102 autoantibodies (23%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). In adult myositis, anti\u2010cortactin was associated with DM skin involvement (62% of patients with anti\u2010cortactin versus 38% of patients without anti\u2010cortactin; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), dysphagia (36% versus 17%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and coexisting anti\u2013Ro 52 autoantibodies (47% versus 26%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) or anti\u2010NT5c1a autoantibodies (59% versus 33%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Moreover, the titers of anti\u2010cortactin antibodies were higher in patients with interstitial lung disease (0.15 versus 0.12 arbitrary units; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). The prevalence of anti\u2010cortactin autoantibodies was not different in juvenile myositis patients (2%) or in any juvenile myositis subgroup compared to juvenile healthy controls (4%). Nonetheless, juvenile myositis patients with these autoantibodies had a higher prevalence of \u201cmechanic's hands\u201d (25% versus 7%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), a higher number of hospitalizations (2.9 versus 1.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), and lower peak creatine kinase values (368 versus 818 IU\/liter; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) than those without anti\u2010cortactin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of anti\u2010cortactin autoantibodies is increased in adult DM patients with coexisting anti\u2013Mi\u20102 or anti\u2013NXP\u20102 autoantibodies. In adults, anti\u2010cortactin autoantibodies are associated with dysphagia and interstitial lung disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41931","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T06:52:05Z","timestamp":1627368725000},"page":"358-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>Anti\u2010Cortactin<\/scp> Autoantibodies Are Associated With Key Clinical Features in Adult Myositis But Are Rarely Present in Juvenile Myositis"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-9218","authenticated-orcid":false,"given":"Iago","family":"Pinal\u2010Fernandez","sequence":"first","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, Johns Hopkins University School of Medicine, Baltimore, Maryland, and Universitat Oberta de Catalunya  Barcelona 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