{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:52:41Z","timestamp":1777510361242,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate premenopausal women with longstanding rheumatoid arthritis (RA) for potential associations between parameters of localized bone involvement and parameters of systemic bone involvement in the affected joints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty consecutively evaluated premenopausal women with RA were included in the study, along with 160 healthy female control subjects who were matched to the patients by age and body mass index. Volumetric bone mineral density (vBMD), bone microarchitecture, and finite elements of biomechanical bone strength (bone stiffness and estimated failure load) at the distal radius and distal tibia were analyzed by high\u2010resolution peripheral quantitative computed tomography (HR\u2010pQCT) in patients with RA compared to healthy controls. In addition, in patients with RA, localized bone involvement in the metacarpophalangeal and proximal interphalangeal joints was analyzed by HR\u2010pQCT, to identify bone erosions and osteophytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 80 premenopausal women with longstanding RA, the mean\u2009\u00b1\u2009SD age was 39.4\u2009\u00b1\u20096.7\u2009years and mean\u2009\u00b1\u2009SD disease duration was 9.8\u2009\u00b1\u20095.3\u2009years. Trabecular and cortical bone parameters and bone strength at the distal radius and distal tibia were all impaired in patients with RA compared to healthy controls (each <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In total, 75% of RA patients had evidence of bone erosions, and 41.3% of RA patients had detectable osteophytes on HR\u2010pQCT. RA patients with bone erosions, as compared to RA patients without bone erosions, had lower cortical vBMD (at the distal radius, mean\u2009\u00b1\u2009SD 980\u2009\u00b1\u200972 mg HA\/cm<jats:sup>3<\/jats:sup> versus 1,021\u2009\u00b1\u200947 mg HA\/cm<jats:sup>3<\/jats:sup> [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03]; at the distal tibia, 979\u2009\u00b1\u200947 mg HA\/cm<jats:sup>3<\/jats:sup> versus 1,003\u2009\u00b1\u200934 mg HA\/cm<jats:sup>3<\/jats:sup> [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04]) and higher cortical bone porosity (at the distal radius, mean\u2009\u00b1\u2009SD 2.8\u2009\u00b1\u20092.5% versus 1.8\u2009\u00b1\u20091.6% [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04]; at the distal tibia, 3.7\u2009\u00b1\u20091.6% versus 2.7\u2009\u00b1\u20091.6% [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01]). In patients with RA, osteophyte volume at the distal radius was positively correlated with trabecular vBMD (r\u00a0=\u00a00.392, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), trabecular number (r\u00a0=\u00a00.381, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), and trabecular stiffness (r\u00a0=\u00a00.411, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), and negatively correlated with trabecular separation (r\u00a0=\u00a0\u22120.364, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), as determined by Pearson's or Spearman's correlation test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings show that premenopausal women with longstanding RA have systemic bone fragility at peripheral joint sites. Moreover, the presence of bone erosions is mainly associated with cortical bone fragility at the distal radius and tibia, and presence of osteophytes is associated with repair of trabecular bone at the distal radius.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.41961","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T02:32:15Z","timestamp":1630377135000},"page":"407-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of Bone Erosions and Osteophytes With Systemic Bone Involvement on <scp>High\u2010Resolution<\/scp> Peripheral Quantitative Computed Tomography in Premenopausal Women With Longstanding Rheumatoid Arthritis"],"prefix":"10.1002","volume":"74","author":[{"given":"Mariana O.","family":"Perez","sequence":"first","affiliation":[{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-8175","authenticated-orcid":false,"given":"Camille P.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas P.","family":"Sales","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"Medeiros\u2010Ribeiro","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliam","family":"Takayama","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo S.","family":"Domiciano","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Bonfiglioli","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria F.","family":"Caparbo","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-5028","authenticated-orcid":false,"given":"Rosa M. R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1443","article-title":"Correlation between systemic osteoporosis and local bone erosion with rheumatoid arthritis patients in Chinese population","volume":"58","author":"Gong X","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24551"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.03.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2020.100282"},{"key":"e_1_2_7_6_1","first-page":"304","article-title":"Bone erosions in rheumatoid arthritis: recent developments in pathogenesis and therapeutic implications [review]","volume":"18","author":"Panagopoulos PK","year":"2018","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.10.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225552"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006983"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket259"},{"key":"e_1_2_7_11_1","first-page":"2171","article-title":"Automated three\u2010dimensional registration of high\u2010resolution peripheral quantitative computed tomography data to quantify size and shape changes of arthritic bone erosions","volume":"54","author":"T\u00f6pfer D","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160648"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3466"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-018-0255-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30285"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201982"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2109"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39698"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1740"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg072"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2007.12.007"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080915"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3876-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1258"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2014.07.010"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew332"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3461-y"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27252"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.09.011"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14157"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.5.427"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205428"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1793"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200003)43:3<522::AID-ANR7>3.0.CO;2-Y"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4170-5"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.10.685"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:4:3:263"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2010.01485.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100829"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40148"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-018-0016-5"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09363-2"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.153"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090320"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.148395"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0552-8"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket353"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.41961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.41961","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.41961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:19:39Z","timestamp":1759954779000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.41961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,25]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/art.41961"],"URL":"https:\/\/doi.org\/10.1002\/art.41961","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,25]]},"assertion":[{"value":"2021-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}