{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:05:10Z","timestamp":1792047910802,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["2R\u201001\u2010AR062173"],"award-info":[{"award-number":["2R\u201001\u2010AR062173"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was undertaken to identify the mechanistic role of \u03b3\u03b4 T cells in the pathogenesis of experimental psoriatic arthritis (PsA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we performed interleukin\u201023 (IL\u201023) gene transfer in wild\u2010type (WT) and T cell receptor \u03b4\u2013deficient (TCR\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup>) mice and conducted tissue phenotyping in the joint, skin, and nails to characterize the inflammatory infiltrate. We further performed detailed flow cytometry, immunofluorescence staining, RNA sequencing, T cell repertoire analysis, and in vitro T cell polarization assays to identify regulatory mechanisms of \u03b3\u03b4 T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We demonstrated that \u03b3\u03b4 T cells support systemic granulopoiesis, which is critical for murine PsA\u2010like pathology. Briefly, \u03b3\u03b4 T cell ablation inhibited the expression of neutrophil chemokines CXCL1 and CXCL2 and neutrophil CD11b+Ly6G+ accumulation in the aforementioned PsA\u2010related tissues. Although significantly reduced expression of granulocyte\u2013macrophage colony\u2010stimulating factor (GM\u2010CSF) and IL\u201017A was detected systemically in TCR\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup> mice, no GM\u2010CSF+\/IL\u201017A+ \u03b3\u03b4 T cells were detected locally in the inflamed skin or bone marrow in WT mice. Our data showed that nonresident \u03b3\u03b4 T cells regulate the expansion of an CD11b+Ly6G+ neutrophil population and their recruitment to joint and skin tissues, where they develop hallmark pathologic features of human PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings do not support the notion that tissue\u2010resident \u03b3\u03b4 T cells initiate the disease but demonstrate a novel role of \u03b3\u03b4 T cells in neutrophil regulation that can be exploited therapeutically in PsA patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42124","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T12:43:26Z","timestamp":1648039406000},"page":"1524-1534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Peripheral \u03b3\u03b4 T Cells Regulate Neutrophil Expansion and Recruitment in Experimental Psoriatic 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