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Our objective was to develop and validate a risk score for patients who have subclinical RA\u2010ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study included a discovery population and a replication population from 2 prospective RA cohorts (ESPOIR and TRANSLATE2, respectively) without pulmonary symptoms who had received chest HRCT scans. All patients were genotyped for <jats:italic>MUC5B<\/jats:italic> rs35705950. After multiple logistic regression, a risk score based on independent risk factors for subclinical RA\u2010ILD was developed in the discovery population and tested for validation in the replication population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The discovery population included 163 patients with RA, and the replication population included 89 patients with RA. The prevalence of subclinical RA\u2010ILD was 19.0% and 16.9%, respectively. In the discovery population, independent risk factors for subclinical RA\u2010ILD were presence of the <jats:italic>MUC5B<\/jats:italic> rs35705950 T allele (odds ratio [OR] 3.74 [95% confidence interval (95% CI) 1.37, 10.39]), male sex (OR 3.93 [95% CI 1.40, 11.39]), older age at RA onset (for each year, OR 1.10 [95% CI 1.04, 1.16]), and increased mean Disease Activity Score in 28 joints using the erythrocyte sedimentation rate (for each unit, OR 2.03 [95% CI 1.24, 3.42]). We developed and validated a derived risk score with receiver operating characteristic areas under the curve of 0.82 (95% CI 0.70\u20130.94) for the discovery population and 0.78 (95% CI 0.65\u20130.92) for the replication population. Excluding <jats:italic>MUC5B<\/jats:italic> rs35705950 from the model provided a lower goodness of fit (likelihood ratio test, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We developed and validated a risk score that could help identify patients at high risk of subclinical RA\u2010ILD. Our findings support an important contribution of <jats:italic>MUC5B<\/jats:italic> rs35705950 to subclinical RA\u2010ILD risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42162","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T11:51:22Z","timestamp":1652874682000},"page":"1755-1765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["A Risk Score to Detect Subclinical Rheumatoid Arthritis\u2013Associated Interstitial Lung Disease"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3766-9600","authenticated-orcid":false,"given":"Pierre\u2010Antoine","family":"Juge","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM UMR 1152, F\u201075018, and Service de Rhumatologie, H\u00f4pital Bichat\u2010Claude Bernard  AP\u2010HP, F\u201075018 Paris 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