{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:52:36Z","timestamp":1792047156538,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["01KG1204"],"award-info":[{"award-number":["01KG1204"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008835","name":"RUB Research School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In active early rheumatoid arthritis (RA), glucocorticoids are often used for bridging, due to the delayed action of methotrexate. This study was undertaken to compare the effect of 3 bridging strategies, including high\u2010dose and low\u2010dose prednisolone, on radiographic and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult RA patients from 1 rheumatology hospital and 23 rheumatology practices who presented with moderate\/high disease activity were randomized (1:1:1) to receive 60 mg prednisolone (high\u2010dose prednisolone [HDP]) or 10 mg prednisolone (low\u2010dose prednisolone [LDP]) daily (tapered to 0 mg within 12\u2009weeks) or placebo. The 12\u2010week intervention period was followed by 40\u2009weeks of therapy at the physicians' discretion. The primary outcome measure was radiographic change at 1 year measured using the total modified Sharp\/van der Heijde score (SHS). Disease activity was assessed with the Disease Activity Score in 28 joints using the erythrocyte sedimentation rate (DAS28\u2010ESR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 395 randomized patients (HDP, n\u00a0=\u00a0132; LDP, n\u00a0=\u00a0131; placebo, n\u00a0=\u00a0132), 375 (95%) remained in the modified intention\u2010to\u2010treat analysis. Mean\u2009\u00b1\u2009SD changes in SHS scores in the 3 groups after 1 year were comparable: mean\u2009\u00b1\u2009SD 1.0\u2009\u00b1\u20092.0 units in the HDP group, 1.1\u2009\u00b1\u20092.2 units in the LDP group, and 1.1\u2009\u00b1\u20091.5 units in the placebo group. The primary analysis showed no superiority of HDP compared to placebo (estimated difference of the mean change \u22120.04 [95% confidence interval (95% CI) \u22120.5, 0.4]). At week 12, the mean DAS28\u2010ESR differed: \u22120.6 (95% CI \u22121.0, \u22120.2) for HDP versus placebo; \u20130.8 (95% CI \u22121.2, \u22120.5) for LDP versus placebo. At week 52, there was no significant difference in DAS28\u2010ESR between the 3 groups (range 2.6\u20132.8). Serious adverse events occurred similarly often.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Short\u2010term glucocorticoid bridging therapy at a high dose showed no benefit with regard to progression of radiographic damage at 1 year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.42245","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T12:58:56Z","timestamp":1653829136000},"page":"1628-1637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Efficacy of\n                    <scp>Short\u2010Term<\/scp>\n                    Bridging Strategies With High\u2010 and\n                    <scp>Low\u2010Dose<\/scp>\n                    Prednisolone on Radiographic and Clinical Outcomes in Active Early Rheumatoid Arthritis: A\n                    <scp>Double\u2010Blind<\/scp>\n                    , Randomized,\n                    <scp>Placebo\u2010Controlled<\/scp>\n                    Trial"],"prefix":"10.1002","volume":"74","author":[{"given":"Dietmar","family":"Krause","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology, Ruhr University Bochum, Bochum, Germany, and Rheumatology Practice Gladbeck  Gladbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-8560","authenticated-orcid":false,"given":"Anna","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Klaassen\u2010Mielke","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology Ruhr University Bochum  Bochum 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Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Rheumatology Practice Hattingen  Hattingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claas","family":"Fendler","sequence":"additional","affiliation":[{"name":"Rheumatology Practice Duisburg  Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Klink","sequence":"additional","affiliation":[{"name":"Rheumatology Practice Gladbeck  Gladbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Boeddeker","sequence":"additional","affiliation":[{"name":"Rheumatology Practice Marl  Marl Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertan","family":"Saracbasi\u2010Zender","sequence":"additional","affiliation":[{"name":"Rheumatology Practice Oberhausen  Oberhausen 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