{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:47:07Z","timestamp":1781304427529,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>T cells are critical in the pathogenesis of systemic lupus erythematosus (SLE) in that they secrete inflammatory cytokines, help autoantibody production, and form autoreactive memory T cells. Although the contribution of T cells to several forms of organ\u2010mediated damage in SLE has been previously demonstrated, the role of T cells in neuropsychiatric SLE (NPSLE), which involves diffuse central nervous system manifestations and is observed in 20\u201340% of SLE patients, is not known. Therefore, we conducted this study to evaluate how behavioral deficits are altered after depletion or transfer of T cells, to directly assess the role of T cells in NPSLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MRL\/<jats:italic>lpr<\/jats:italic> mice, an NPSLE mouse model, were either systemically depleted of CD4+ T cells or intracerebroventricularly injected with choroid plexus (CP)\u2013infiltrating T cells and subsequently evaluated for alterations in neuropsychiatric manifestations. Our study end points included evaluation of systemic disease and assessment of central nervous system changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Systemic depletion of CD4+ T cells ameliorated systemic disease and cognitive deficits. Intracerebroventricular injection of CP\u2013infiltrating T cells exacerbated depressive\u2010like behavior and worsened cognition in recipient mice compared with mice who received injection of splenic lupus T cells or phosphate buffered saline. Moreover, we observed enhanced activation in CP\u2013infiltrating T cells when cocultured with brain lysate\u2013pulsed dendritic cells in comparison to the activation levels observed in cocultures with splenic T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T cells, and more specifically CP\u2013infiltrating antigen\u2010specific T cells, contributed to the pathogenesis of NPSLE in mice, indicating that, in the development of more targeted treatments for NPSLE, modulation of T cells may represent a potential therapeutic strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42252","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T23:59:06Z","timestamp":1653955146000},"page":"1796-1807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Choroid Plexus\u2013Infiltrating T Cells as Drivers of Murine Neuropsychiatric Lupus"],"prefix":"10.1002","volume":"74","author":[{"given":"Erica","family":"Moore","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Division of Rheumatology Albert Einstein College of Medicine  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle W.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Division of Rheumatology Albert Einstein College of Medicine  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara A.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Pathology Albert Einstein College of Medicine  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Macian","sequence":"additional","affiliation":[{"name":"Department of Pathology Albert Einstein College of Medicine  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3204-6068","authenticated-orcid":false,"given":"Chaim","family":"Putterman","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine of Bar\u2010Ilan University, Safed, Israel, Galilee Research Institute, Nahariya, Israel, and Department of Microbiology and Immunology, Division of Rheumatology Albert Einstein College of Medicine  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100359"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314556139"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1995.0003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(92)90166-M"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.4049\/jimmunol.157.7.3159","article-title":"Anti\u2010CD40 ligand antibody treatment prevents the development of lupus\u2010like nephritis in a subset of New Zealand black x New Zealand white mice. 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