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This challenge is highlighted by certain autoinflammatory diseases that arise from monogenic mutations and result in periodic flares of inflammation, typically in the absence of autoantibodies or antigen\u2010specific T lymphocytes. Several autoinflammatory diseases arise due to mutations in genes that normally prevent the accrual of endogenous DNA or are due to mutations that cause activation of intracellular DNA\u2013sensing pathway components. Evidence from genetically modified murine models further support an ability of endogenous DNA and DNA sensing to drive disease pathogenesis, prompting the question of whether endogenous DNA can also induce inflammation in human autoimmune diseases. In this review, we discuss the current understanding of intracellular DNA sensing and downstream signaling pathways as they pertain to autoinflammatory disease, including the development of monogenic disorders such as Stimulator of interferon genes\u2013associated vasculopathy with onset in infancy and Aicardi\u2010Gouti\u00e8res syndrome. In addition, we discuss systemic rheumatic diseases, including certain forms of systemic lupus erythematosus, familial chilblain lupus, and other diseases with established links to intracellular DNA\u2013sensing pathways, and highlight the lessons learned from these examples as they apply to the development of therapies targeting these pathways.<\/jats:p>","DOI":"10.1002\/art.42256","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T06:29:51Z","timestamp":1654237791000},"page":"1615-1624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Intracellular Sensing of <scp>DNA<\/scp> in Autoinflammation and Autoimmunity"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-0826","authenticated-orcid":false,"given":"Susan","family":"MacLauchlan","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Inflammation, and Immunity, Department 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