{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:00:02Z","timestamp":1792519202366,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000960","name":"American College of Rheumatology Research and Education Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000960","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007211","name":"Vasculitis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and validate updated classification criteria for giant cell arteritis (GCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 6 phases: 1) identification of candidate items, 2) prospective collection of candidate items present at the time of diagnosis, 3) expert panel review of cases, 4) data\u2010driven reduction of candidate items, 5) derivation of a points\u2010based risk classification score in a development data set, and 6) validation in an independent data set.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The development data set consisted of 518 cases of GCA and 536 comparators. The validation data set consisted of 238 cases of GCA and 213 comparators. Age\u2009\u226550\u2009years at diagnosis was an absolute requirement for classification. The final criteria items and weights were as follows: positive temporal artery biopsy or temporal artery halo sign on ultrasound (+5); erythrocyte sedimentation rate\u2009\u226550\u2009mm\/hour or C\u2010reactive protein \u226510 mg\/liter (+3); sudden visual loss (+3); morning stiffness in shoulders or neck, jaw or tongue claudication, new temporal headache, scalp tenderness, temporal artery abnormality on vascular examination, bilateral axillary involvement on imaging, and fluorodeoxyglucose\u2013positron emission tomography activity throughout the aorta (+2 each). A patient could be classified as having GCA with a cumulative score of \u22656 points. When these criteria were tested in the validation data set, the model area under the curve was 0.91 (95% confidence interval [95% CI] 0.88\u20130.94) with a sensitivity of 87.0% (95% CI 82.0\u201391.0%) and specificity of 94.8% (95% CI 91.0\u201397.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 2022 American College of Rheumatology\/EULAR GCA classification criteria are now validated for use in clinical research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.42325","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T02:35:39Z","timestamp":1667961339000},"page":"1881-1889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":220,"title":["2022 American College of Rheumatology\/EULAR Classification Criteria for Giant Cell 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Research Centre, University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Khalid","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences Oxford NIHR Biomedical Research Centre, University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0215-9923","authenticated-orcid":false,"given":"Andrew","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Department of Health Services Research and Policy London School of Hygiene and Tropical Medicine  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-4769","authenticated-orcid":false,"given":"Richard A.","family":"Watts","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences Oxford NIHR Biomedical Research Centre, 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