{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:46Z","timestamp":1786977106972,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS066274\u201010"],"award-info":[{"award-number":["NS066274\u201010"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to identify blood markers of juvenile dermatomyositis (DM) disease activity (DA), which are needed to improve disease management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study comprised a total of 123 juvenile DM patients and 53 healthy controls. Results of laboratory tests (aldolase, creatinine kinase, lactate dehydrogenase [LDH], aspartate aminotransferase) and clinical measures of DA in patients with juvenile DM, including the Manual Muscle Testing in 8 muscles (MMT\u20108), Childhood Myositis Assessment Scale (CMAS), and disease activity scores (DAS) (total DAS for juvenile DM, the muscle DAS, and the skin DAS), were recorded when available. Surface phenotype of peripheral blood mononuclear cells was assessed using flow cytometry. Whole blood transcriptional profiles were studied using either RNA\u2010sequencing or microarrays. Differential gene expression was determined using DESeq and compared by pathway and gene ontology analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Conventional memory (CD27+IgD\u2013) B cells expressing low CXCR5 levels (CXCR5\n                      <jats:sup>low\/\u2013<\/jats:sup>\n                      CM B cells) were significantly increased in frequency and absolute numbers in 2 independent cohorts of juvenile DM patients compared with healthy controls. The frequency of CD4+ Th2 memory cells (CD45RA\u2013CXCR5\u2013CCR6\u2013CXCR3\u2013) was also increased in juvenile DM, especially in patients who were within &lt;1 year from diagnosis. The frequency of CXCR5\n                      <jats:sup>low\/\u2013<\/jats:sup>\n                      CM B cells correlated with serum aldolase levels and with a blood interferon\u2010stimulated gene transcriptional signature. Furthermore, both the frequency and absolute numbers of CXCR5\n                      <jats:sup>low\/\u2013<\/jats:sup>\n                      CM B cells correlated with clinical and laboratory measures of muscle DA (MMT\u20108, CMAS, aldolase, and LDH).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that both CM B cells lacking the CXCR5 follicular marker and CXCR5\u2013 Th2 cells represent potential biomarkers of DA in juvenile DM and may contribute to its pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.42446","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T11:30:35Z","timestamp":1673955035000},"page":"1246-1261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of Juvenile Dermatomyositis Disease Activity With the Expansion of Blood Memory B and T Cell Subsets Lacking Follicular Markers"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-6176","authenticated-orcid":false,"given":"Jacqueline S.","family":"Gofshteyn","sequence":"first","affiliation":[{"name":"Department of Pediatrics Weill Cornell Medical College  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Weill Cornell Medical College, and Department of Pediatrics Hospital for Special Surgery  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Spitznagle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Washington School of Medicine  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetha","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medical College  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Health  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Miller","sequence":"additional","affiliation":[{"name":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medical College  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Gu","sequence":"additional","affiliation":[{"name":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medical College  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Health  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilynn","family":"Punaro","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center and Texas Scottish Rite Hospital for Children  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Fuller","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center and Texas Scottish Rite Hospital for Children  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorien","family":"Nassi","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center and Texas Scottish Rite Hospital for Children  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Stewart","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center and Texas Scottish Rite Hospital for Children  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Ohouo","sequence":"additional","affiliation":[{"name":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medical College  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristy","family":"Stagnar","sequence":"additional","affiliation":[{"name":"Clemson University College of Behavioral Social and Health Sciences  Clemson South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine","family":"Baisch","sequence":"additional","affiliation":[{"name":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medical College  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynnette","family":"Walters","sequence":"additional","affiliation":[{"name":"Texas Scottish Rite Hospital for Children  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; 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