{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:07Z","timestamp":1787237707754,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000837","name":"University of Nottingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Previous studies demonstrated that the risk of venous thromboembolism (VTE) is increased in patients with gout, but not whether there was a temporal association between gout flare and VTE. This study was undertaken to evaluate potential temporal associations between gout flare and VTE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were obtained from electronic primary\u2010care records from the UK's Clinical Practice Research Datalink, which links data from hospitalization and mortality registers. Using self\u2010controlled case series analysis adjusted for season and age, we evaluated the temporal association between gout flare and VTE. The 90\u2009days after primary\u2010care consultation or hospitalization for gout flare was designated the exposed period. This was divided into three 30\u2010day intervals. The baseline period was up to 2\u2009years before the start of and up to 2\u2009years after the end of the exposed period. The association between gout flare and VTE was measured using adjusted incidence rate ratios (IRRs) with 95% confidence intervals (95% CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 314 patients met the inclusion criteria (age \u226518\u2009years, incident gout, no presence of VTE or use of a primary\u2010care anticoagulant prescription before the start of the pre\u2010exposure period). Among the 314 patients, VTE incidence was significantly higher in the exposed period than in the baseline period (adjusted IRR 1.83, 95% CI 1.30\u20132.59). The adjusted IRR of VTE during the first 30\u2009days after gout flare was 2.31 (95% CI 1.39\u20133.82) relative to the baseline period. No increase in the adjusted IRRs was observed in days 31\u201360 (adjusted IRR 1.49, 95% CI 0.79\u20132.81) and days 61\u201390 (adjusted IRR 1.67, 95% CI 0.91\u20133.06) relative to baseline. Results were consistent across sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients with gout, there was a transient increase in the rate of VTE within 30\u2009days after primary\u2010care consultation or hospitalization for gout flare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.42480","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T02:45:18Z","timestamp":1676947518000},"page":"1638-1647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Risk of Venous Thromboembolism With Gout Flares"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-8197","authenticated-orcid":false,"given":"Edoardo","family":"Cipolletta","sequence":"first","affiliation":[{"name":"Academic Rheumatology, University of Nottingham, Nottingham, UK, and Rheumatology Unit, Department of Clinical and Molecular Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila J.","family":"Tata","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Public Health University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Nakafero","sequence":"additional","affiliation":[{"name":"Academic Rheumatology, University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Avery","sequence":"additional","affiliation":[{"name":"Centre for Academic Primary Care, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Abhishek","sequence":"additional","affiliation":[{"name":"Academic Rheumatology, University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32658-1"},{"key":"e_1_2_6_3_1","unstructured":"Centers for Disease Control and Prevention.Data and statistics on venous thromboembolism. 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