{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:01:54Z","timestamp":1793314914163,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["U54\u2010RR\u2010019497"],"award-info":[{"award-number":["U54\u2010RR\u2010019497"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["U54\u2010AR\u2010057319"],"award-info":[{"award-number":["U54\u2010AR\u2010057319"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007211","name":"Vasculitis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study examined the relationship between age at diagnosis and disease characteristics and damage in patients with antineutrophil cytoplasmic antibody (ANCA)\u2013associated vasculitis (AAV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analysis of a prospective longitudinal cohort of patients with granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic GPA (EGPA) in the Vasculitis Clinical Research Consortium (2013\u20132021). Disease cohorts were divided by age at diagnosis (years): children (&lt;18), young adults (18\u201340), middle\u2010aged adults (41\u201365), and older adults (&gt;65). Data included demographics, ANCA type, clinical characteristics, Vasculitis Damage Index (VDI) scores, ANCA Vasculitis Index of Damage (AVID) scores, and novel disease\u2010specific and non\u2010disease\u2010specific damage scores built from VDI and AVID items.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis included data from 1020 patients with GPA\/MPA and 357 with EGPA. Female predominance in GPA\/MPA decreased with age at diagnosis. AAV in childhood was more often GPA and proteinase 3\u2010ANCA positive. Children with GPA\/MPA experienced more subglottic stenosis and alveolar hemorrhage; children and young adults with EGPA experienced more alveolar hemorrhage, need for intubation, and gastrointestinal involvement. Older adults (GPA\/MPA) had more neurologic manifestations. After adjusting for disease duration, medications, tobacco, and ANCA, all damage scores increased with age at diagnosis for GPA\/MPA (<jats:italic>P<\/jats:italic> &lt;\u20090.001) except the disease\u2010specific damage score, which did not differ (<jats:italic>P<\/jats:italic> =\u20090.44). For EGPA, VDI scores increased with age at diagnosis (<jats:italic>P<\/jats:italic> &lt;\u20090.009), whereas all other scores were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Age at diagnosis is associated with clinical characteristics in AAV. Although VDI and AVID scores increase with age at diagnosis, this is driven by non\u2010disease\u2010specific damage items.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art42651-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42651","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T15:29:39Z","timestamp":1689089379000},"page":"2216-2227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Association Between Age at Diagnosis and Disease Characteristics and Damage in Patients With <scp>ANCA\u2010Associated<\/scp> Vasculitis"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7645-2084","authenticated-orcid":false,"given":"Jessica L.","family":"Bloom","sequence":"first","affiliation":[{"name":"University of Colorado  Denver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaci","family":"Pickett\u2010Nairn","sequence":"additional","affiliation":[{"name":"University of Colorado  Denver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Silveira","sequence":"additional","affiliation":[{"name":"University of Colorado  Denver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Fuhlbrigge","sequence":"additional","affiliation":[{"name":"University of Colorado  Denver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cuthbertson","sequence":"additional","affiliation":[{"name":"University of South Florida  Tampa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Akuthota","sequence":"additional","affiliation":[{"name":"University of California San Diego  La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Corbridge","sequence":"additional","affiliation":[{"name":"US Medical Affairs\u2010Respiratory GSK  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader A.","family":"Khalidi","sequence":"additional","affiliation":[{"name":"St. Joseph's Healthcare Hamilton McMaster University  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curry L.","family":"Koening","sequence":"additional","affiliation":[{"name":"University of Utah  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Langford","sequence":"additional","affiliation":[{"name":"Cleveland Clinic  Cleveland 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