{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:41:48Z","timestamp":1792885308086,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["Food allergy and tolerance (FOOD@\u2013Project ID 428046232)"],"award-info":[{"award-number":["Food allergy and tolerance (FOOD@\u2013Project ID 428046232)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["CRC1449"],"award-info":[{"award-number":["CRC1449"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["CRC\u2010TRR241"],"award-info":[{"award-number":["CRC\u2010TRR241"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["EXC 2155 \u201cRESIST\u201d (Project ID 390874280"],"award-info":[{"award-number":["EXC 2155 \u201cRESIST\u201d (Project ID 390874280"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"\n Objective<\/jats:title>\n Spondyloarthritis (SpA) is a group of immune\u2010mediated diseases highly concomitant with nonmusculoskeletal inflammatory disorders, such as acute anterior uveitis (AAU) and Crohn's disease (CD). The gut microbiome represents a promising avenue to elucidate shared and distinct underlying pathophysiology.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We performed 16S ribosomal RNA sequencing on stool samples of 277 patients (72 CD, 103 AAU, and 102 SpA) included in the German Spondyloarthritis Inception Cohort and 62 back pain controls without any inflammatory disorder. Discriminatory statistical methods were used to disentangle microbial disease signals from one another and a wide range of potential confounders. Patients were naive to or had not received treatment with biological disease\u2010modifying antirheumatic drugs (DMARDs) for >3 months before enrollment, providing a better approximation of a true baseline disease signal.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We identified a shared, immune\u2010mediated disease signal represented by low abundances of Lachnospiraceae taxa relative to controls, most notably\n Fusicatenibacter<\/jats:italic>\n , which was most abundant in controls receiving nonsteroidal antiinflammatory drug monotherapy and implied to partially mediate higher serum C\u2010reactive protein\n .<\/jats:italic>\n Patients with SpA showed an enrichment of\n Collinsella<\/jats:italic>\n , whereas human leukocyte antigen (HLA)\u2010B27+ individuals displayed enriched\n Faecalibacterium<\/jats:italic>\n . CD patients had higher abundances of a\n Ruminococcus<\/jats:italic>\n taxon, and previous conventional\/synthetic DMARD therapy was associated with increased\n Akkermansia<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our work supports the existence of a common gut dysbiosis in SpA and related inflammatory pathologies. We reveal shared and disease\u2010specific microbial associations and suggest potential mediators of disease activity. Validation studies are needed to clarify the role of\n Fusicatenibacter<\/jats:italic>\n in gut\u2010joint inflammation, and metagenomic resolution is needed to understand the relationship between\n Faecalibacterium<\/jats:italic>\n commensals and HLA\u2010B27.\n <\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.42658","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T13:46:00Z","timestamp":1689860760000},"page":"48-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Shared and Distinct Gut Microbiota in Spondyloarthritis, Acute Anterior Uveitis, and Crohn's Disease"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-7497","authenticated-orcid":false,"given":"Morgan","family":"Essex","sequence":"first","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC; a cooperation of the Max Delbr\u00fcck Center and Charit\u00e9\u2013Universit\u00e4tsmedizin), Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), and Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin (a corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2013Universit\u00e4t zu Berlin) Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5612-043X","authenticated-orcid":false,"given":"Valeria","family":"Rios Rodriguez","sequence":"additional","affiliation":[{"name":"Medical Department of Gastroenterology, Infectiology and Rheumatology Campus Benjamin Franklin, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7442-2570","authenticated-orcid":false,"given":"Judith","family":"Rademacher","sequence":"additional","affiliation":[{"name":"Medical Department of Gastroenterology, Infectiology and Rheumatology Campus Benjamin Franklin, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, and Berlin Institute of Health (BIH) at Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-033X","authenticated-orcid":false,"given":"Fabian","family":"Proft","sequence":"additional","affiliation":[{"name":"Medical Department of Gastroenterology, Infectiology and Rheumatology Campus Benjamin Franklin, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"L\u00f6ber","sequence":"additional","affiliation":[{"name":"ECRC, MDC, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin and German Center for Cardiovascular Research (DZHK) Berlin 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