{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:51:04Z","timestamp":1790841064939,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014034","name":"Foundation for Research in Rheumatology","doi-asserted-by":"publisher","award":["045"],"award-info":[{"award-number":["045"]}],"id":[{"id":"10.13039\/501100014034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We previously reported an increased expression of microRNA\u2010155 (miR\u2010155) in the blood monocytes of patients with rheumatoid arthritis (RA) that could be responsible for impaired monocyte polarization to anti\u2010inflammatory M2\u2010like macrophages. In this study, we employed two preclinical models of RA, collagen\u2010induced arthritis and K\/BxN serum transfer arthritis, to examine the therapeutic potential of antagomiR\u2010155\u20105p entrapped within PEGylated (polyethylene glycol [PEG]) liposomes in resolution of arthritis and repolarization of monocytes towards the anti\u2010inflammatory M2 phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>AntagomiR\u2010155\u20105p or antagomiR\u2010control were encapsulated in PEG liposomes of 100 nm in size and \u221210 mV in zeta potential with high antagomiR loading efficiency (above 80%). Mice were injected intravenously with 1.5 nmol\/100 \u03bcL PEG liposomes containing antagomiR\u2010155\u20105p or control after the induction of arthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We demonstrated the biodistribution of fluorescently tagged PEG liposomes to inflamed joints one hour after the injection of fluorescently tagged PEG liposomes, as well as the liver's subsequent accumulation after 48 hours, indicative of hepatic clearance, in mice with arthritis. The injection of PEG liposomes containing antagomiR\u2010155\u20105p decreased arthritis score and paw swelling compared with PEG liposomes containing antagomiR\u2010control or the systemic delivery of free antagomiR\u2010155\u20105p. Moreover, treatment with PEG liposomes containing antagomiR\u2010155\u20105p led to the restoration of bone marrow monocyte defects in anti\u2010inflammatory macrophage differentiation without any significant functional change in other immune cells, including splenic B and T cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The injection of antagomiR\u2010155\u20105p encapsulated in PEG liposomes allows the delivery of small RNA to monocytes and macrophages and reduces joint inflammation in murine models of RA, providing a promising strategy in human disease.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art42665-toc-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.42665","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T12:29:11Z","timestamp":1690892951000},"page":"18-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Liposomal\n                    <scp>AntagomiR<\/scp>\n                    \u2010155\u20105p Restores\n                    <scp>Anti\u2010Inflammatory<\/scp>\n                    Macrophages and Improves Arthritis in Preclinical Models of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-385X","authenticated-orcid":false,"given":"Audrey","family":"Paoletti","sequence":"first","affiliation":[{"name":"Paris\u2010Saclay University, INSERM UMR1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bic\u00eatre  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bineta","family":"Ly","sequence":"additional","affiliation":[{"name":"Paris\u2010Saclay University, INSERM UMR1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bic\u00eatre  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cailleau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, CNRS, Institut Galien Paris\u2010Saclay  Orsay 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