{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:14:58Z","timestamp":1787501698314,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["P01\u2010AT009965"],"award-info":[{"award-number":["P01\u2010AT009965"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R01\u2010AT007550"],"award-info":[{"award-number":["R01\u2010AT007550"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R33\u2010AT009306"],"award-info":[{"award-number":["R33\u2010AT009306"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["P41RR14075"],"award-info":[{"award-number":["P41RR14075"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["S10RR021110"],"award-info":[{"award-number":["S10RR021110"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["S10RR023043"],"award-info":[{"award-number":["S10RR023043"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01\u2010AR064367"],"award-info":[{"award-number":["R01\u2010AR064367"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01\u2010AR079110"],"award-info":[{"award-number":["R01\u2010AR079110"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Fibromyalgia (FM) is characterized by pervasive pain\u2010related symptomatology and high levels of negative affect. Mind\u2013body treatments such as cognitive behavioral therapy (CBT) appear to foster improvement in FM via reductions in pain\u2010related catastrophizing, a set of negative, pain\u2010amplifying cognitive and emotional processes. However, the neural underpinnings of CBT's catastrophizing\u2010reducing effects remain uncertain. This randomized controlled mechanistic trial was designed to assess CBT's effects on pain catastrophizing and its underlying brain circuitry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Of 114 enrolled participants, 98 underwent a baseline neuroimaging assessment and were randomized to 8\u2009weeks of individual CBT or a matched FM education control (EDU) condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with EDU, CBT produced larger decreases in pain catastrophizing post treatment (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.05) and larger reductions in pain interference and symptom impact. Decreases in pain catastrophizing played a significant role in mediating those functional improvements in the CBT group. At baseline, brain functional connectivity between the ventral posterior cingulate cortex (vPCC), a key node of the default mode network (DMN), and somatomotor and salience network regions was increased during catastrophizing thoughts. Following CBT, vPCC connectivity to somatomotor and salience network areas was reduced.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest clinically important and CBT\u2010specific associations between somatosensory\/motor\u2010 and salience\u2010processing brain regions and the DMN in chronic pain. These patterns of connectivity may contribute to individual differences (and treatment\u2010related changes) in somatic self\u2010awareness. CBT appears to provide clinical benefits at least partially by reducing pain\u2010related catastrophizing and producing adaptive alterations in DMN functional connectivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.42672","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T04:01:23Z","timestamp":1695182483000},"page":"130-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A Randomized Controlled Neuroimaging Trial of Cognitive Behavioral Therapy for Fibromyalgia Pain"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-175X","authenticated-orcid":false,"given":"Jeungchan","family":"Lee","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital and Spaulding Rehabilitation Hospital, Harvard Medical School  Charlestown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asimina","family":"Lazaridou","sequence":"additional","affiliation":[{"name":"Brigham &amp; Women's Hospital, Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrella","family":"Paschali","sequence":"additional","affiliation":[{"name":"Brigham &amp; Women's Hospital, Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco L.","family":"Loggia","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School  Charlestown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Berry","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School  Charlestown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-3832","authenticated-orcid":false,"given":"Dan\u2010Mikael","family":"Ellingsen","sequence":"additional","affiliation":[{"name":"Kristiania University College and Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Isenburg","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School  Charlestown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9377-5152","authenticated-orcid":false,"given":"Alessandra","family":"Anzolin","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Spaulding Rehabilitation Hospital, Harvard Medical School  Charlestown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvina","family":"Grahl","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Spaulding Rehabilitation Hospital, Harvard Medical School  Charlestown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay D.","family":"Wasan","sequence":"additional","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Napadow","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Spaulding Rehabilitation Hospital, Harvard Medical School  Charlestown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Brigham &amp; Women's Hospital, Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00392-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.9276"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/15291006211008157"},{"key":"e_1_2_7_5_1","first-page":"CD007407","article-title":"Psychological therapies for the management of chronic pain (excluding headache) in adults","volume":"8","author":"Williams ACC","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223367"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13142-011-0086-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6266619"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000422"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002134"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001541"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S192246"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.02.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.04.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39043"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38191"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0425-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34412"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27497"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40507"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20156"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2005.08.003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10608-012-9476-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.09.012"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2783"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.7.4.524"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.09.034"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24898"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2010.536197"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(68)90028-4"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1704"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.757241"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.08.013"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1037\/ccp0000612"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.01.014"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5055-13.2014"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16080883"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.12.017"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2013.10.001"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2022.08.010"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001417"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.11.009"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001401"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0362-2"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0037208"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.603420"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.04.016"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000602"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2016.01.001"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:59:55Z","timestamp":1759946395000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.42672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,21]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/art.42672"],"URL":"https:\/\/doi.org\/10.1002\/art.42672","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,21]]},"assertion":[{"value":"2023-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}