{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:54:54Z","timestamp":1790283294324,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30\u2010AR070253"],"award-info":[{"award-number":["P30\u2010AR070253"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01\u2010AR065538"],"award-info":[{"award-number":["R01\u2010AR065538"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01\u2010AR073201"],"award-info":[{"award-number":["R01\u2010AR073201"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01\u2010AR075906"],"award-info":[{"award-number":["R01\u2010AR075906"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["K Supplement Award"],"award-info":[{"award-number":["K Supplement Award"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Kawasaki disease (KD) is a systemic vasculitis of young children that can lead to development of coronary artery aneurysms. We aimed to identify diagnostic markers to distinguish KD from other pediatric inflammatory diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the proximity extension assay to profile proinflammatory mediators in plasma samples from healthy pediatric controls (n\u00a0=\u00a030), febrile controls (n\u00a0=\u00a026), and patients with KD (n\u00a0=\u00a023), multisystem inflammatory syndrome in children (MIS\u2010C; n\u00a0=\u00a025), macrophage activation syndrome (n\u00a0=\u00a013), systemic and nonsystemic juvenile idiopathic arthritis (n\u00a0=\u00a014 and n\u00a0=\u00a010, respectively), and juvenile dermatomyositis (n\u00a0=\u00a09). We validated the key findings using serum samples from additional patients with KD (n\u00a0=\u00a037) and febrile controls (n\u00a0=\u00a028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High\u2010fidelity proteomic profiling revealed distinct patterns of cytokine and chemokine expression across pediatric inflammatory diseases. Although KD and MIS\u2010C exhibited many similarities, KD differed from MIS\u2010C and other febrile diseases in that most patients exhibited elevation in one or more members of the interleukin\u201017 (IL\u201017) cytokine family, IL\u201017A, IL\u201017C, and IL\u201017F. IL\u201017A was particularly sensitive and specific, discriminating KD from febrile controls with an area under the receiver operator characteristic curve of 0.95 (95% confidence interval 0.89\u20131.00) in the derivation set and 0.91 (0.85\u20130.98) in the validation set. Elevation of all three IL\u201017\u2010family cytokines was observed in over 50% of KD patients, including 19 of 20 with coronary artery aneurysms, but was rare in all other comparator groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevation of IL\u201017 family cytokines is a hallmark of KD and may help distinguish KD from its clinical mimics.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art42680-toc-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.42680","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T09:19:32Z","timestamp":1692782372000},"page":"285-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Elevation of\n                    <scp>IL<\/scp>\n                    \u201017 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders"],"prefix":"10.1002","volume":"76","author":[{"given":"Kailey E.","family":"Brodeur","sequence":"first","affiliation":[{"name":"Boston Children's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital, Boston, Massachusetts, and Guangdong Second Provincial General Hospital  Guangzhou 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