{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:50:34Z","timestamp":1781340634863,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007172","name":"Cincinnati Children's","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30 AR076316"],"award-info":[{"award-number":["P30 AR076316"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR074795"],"award-info":[{"award-number":["R01 AR074795"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Juvenile\u2010onset fibromyalgia (JFM) is a paradigmatic chronic pain condition for which the underlying neurobiological substrates are poorly understood. This study examined, for the first time, data\u2010driven resting\u2010state functional connectivity (rsFC) alterations in 37 female adolescents with JFM compared with 43 healthy female adolescents and identified associations with bodily pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Whole\u2010brain voxel\u2010wise rsFC alterations were assessed using the intrinsic connectivity contrast, a measure of node centrality at each voxel, and seed\u2010based analyses for interpretability. We studied the relationship between rsFC alterations in somatosensory systems and the location and extension of bodily pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adolescents with JFM had voxel\u2010wise rsFC reductions in the paracentral lobule (PCL)\/primary somatosensory cortex (S1) (T\u00a0=\u00a04.89, family\u2010wise error corrected p\u2010value (pFWE)\u00a0&lt;\u20090.001) and left midcingulate cortex (T\u00a0=\u00a04.67, pFWE\u00a0=\u00a00.043). Post hoc analyses revealed reduced rsFC spanning major cortical sensory hubs (T &gt;\u20094.4, pFWE &lt;\u20090.030). Cortico\u2010cortical rsFC reductions within PCL\/S1 in JFM occurred in locations innervated by bodily areas where the pain was most frequent (F\u00a0=\u00a03.15; positive false discovery rate\u00a0=\u00a00.029) and predicted widespread pain (T &gt;\u20094.4, pFWE &lt;\u20090.045). Conversely, adolescents with JFM had increases in PCL\/S1\u2013thalamus (T\u00a0=\u00a04.75, pFWE\u00a0=\u00a00.046) and PCL\/S1\u2013anterior insula rsFC (T\u00a0=\u00a05.13, pFWE\u00a0=\u00a00.039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced cortico\u2010cortical sensory integration involving PCL\/S1 and spanning the sensory systems may underly critical pain sensory features in youth with JFM. Reduced sensory integration is paralleled by augmented cross\u2010talk between sensory and affective\/salience\u2010processing regions, potentially indicating a shift toward more affectively colored sensory experiences to the detriment of specific sensory discrimination.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42691","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T04:21:45Z","timestamp":1693801305000},"page":"293-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Reduced <scp>Cortico\u2010Cortical Resting\u2010State<\/scp> Connectivity in Sensory Systems Related to Bodily Pain in Juvenile Fibromyalgia"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4731-4811","authenticated-orcid":false,"given":"Maria","family":"Su\u00f1ol","sequence":"first","affiliation":[{"name":"University of Barcelona  Barcelona 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