{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:24:35Z","timestamp":1791919475291,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1UL1\u2010TR\u2010001445"],"award-info":[{"award-number":["1UL1\u2010TR\u2010001445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K24\u2010AR\u2010070892"],"award-info":[{"award-number":["K24\u2010AR\u2010070892"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30\u2010AR\u2010072571"],"award-info":[{"award-number":["P30\u2010AR\u2010072571"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U54\u2010GM\u2010115458"],"award-info":[{"award-number":["U54\u2010GM\u2010115458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"VA","doi-asserted-by":"publisher","award":["I01\u2010CX\u2010002358"],"award-info":[{"award-number":["I01\u2010CX\u2010002358"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX004600"],"award-info":[{"award-number":["BX004600"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Using trial data comparing treat\u2010to\u2010target allopurinol and febuxostat in gout, we examined participant characteristics associated with serum urate (SU) goal achievement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with gout and SU \u22656.8 mg\/dL were randomized to allopurinol or febuxostat, titrated during weeks 0 to 24, and maintained weeks 25 to 48. Participants were considered to achieve SU goal if the mean SU from weeks 36, 42, and 48 was &lt;6.0 mg\/dL or &lt;5 mg\/dL if tophi were present. Possible determinants of treatment response were preselected and included sociodemographics, comorbidities, diuretic use, health\u2010related quality of life (HRQoL), body mass index, and gout measures. Determinants of SU response were assessed using multivariable logistic regression with additional analyses to account for treatment adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 764 study participants completing week 48, 618 (81%) achieved SU goal. After multivariable adjustment, factors associated with a greater likelihood of SU goal achievement included older age (adjusted odds ratio [aOR] 1.40 per 10\u2009years), higher education (aOR 2.02), and better HRQoL (aOR 1.17 per 0.1 unit). Factors associated with a lower odds of SU goal achievement included non\u2010White race (aORs 0.32\u20130.47), higher baseline SU (aOR 0.83 per 1 mg\/dL), presence of tophi (aOR 0.29), and the use of diuretics (aOR 0.52). Comorbidities including chronic kidney disease, hypertension, diabetes, and cardiovascular disease were not associated with SU goal achievement. Results were not meaningfully changed in analyses accounting for adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Several patient\u2010level factors were predictive of SU goal achievement among patients with gout who received treat\u2010to\u2010target urate\u2010lowering therapy (ULT). Approaches that accurately predict individual responses to treat\u2010to\u2010target ULT hold promise in facilitating personalized management and improving outcomes in patients with gout.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42731","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:07:25Z","timestamp":1697440045000},"page":"638-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Determinants of Achieving Serum Urate Goal with <scp>Treat\u2010to\u2010Target Urate\u2010Lowering<\/scp> Therapy in Gout"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7716-209X","authenticated-orcid":false,"given":"Lindsay N.","family":"Helget","sequence":"first","affiliation":[{"name":"Veterans Affairs (VA) Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"O'Dell","sequence":"additional","affiliation":[{"name":"Veterans Affairs (VA) Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff A.","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Veterans Affairs (VA) Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Androsenko","sequence":"additional","affiliation":[{"name":"VA Boston Cooperative Studies Program Coordinating Center  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary T.","family":"Brophy","sequence":"additional","affiliation":[{"name":"VA Boston Cooperative Studies Program Coordinating Center and Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Davis\u2010Karim","sequence":"additional","affiliation":[{"name":"VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-3588","authenticated-orcid":false,"given":"Bryant R.","family":"England","sequence":"additional","affiliation":[{"name":"Veterans Affairs (VA) Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Ferguson","sequence":"additional","affiliation":[{"name":"VA Boston Cooperative Studies Program Coordinating Center and Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-1542","authenticated-orcid":false,"given":"Michael H.","family":"Pillinger","sequence":"additional","affiliation":[{"name":"VA New York Harbor Health Care System and New York University Grossman School of Medicine  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-1711","authenticated-orcid":false,"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[{"name":"Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Palevsky","sequence":"additional","affiliation":[{"name":"VA Pittsburgh Health Care System and University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Wu","sequence":"additional","affiliation":[{"name":"VA Boston Cooperative Studies Program Coordinating Center, Boston, and Babson College  Wellesley Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Kramer","sequence":"additional","affiliation":[{"name":"Veterans Affairs (VA) Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-2272","authenticated-orcid":false,"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[{"name":"Veterans Affairs (VA) Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315618393"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24180"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209707"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32158-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1169"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140588"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190522"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40486"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.7.925"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001628"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210872"},{"key":"e_1_2_6_13_1","article-title":"Comparative effectiveness of allopurinol and febuxostat in gout management","volume":"1","author":"O'Dell JR","year":"2022","journal-title":"NEJM Evid"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2018.03.015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208237"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21772"},{"key":"e_1_2_6_17_1","unstructured":"FDA adds Boxed Warning for increased risk of death with gout medicine Uloric (febuxostat).US Food and Drug Administration. 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