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Gait biomechanics were collected from individuals 6 to 12 months post\u2010ACLR (n\u00a0=\u00a036), uninjured controls matched to the ACLR group (n\u00a0=\u00a036), and individuals with KL2 (n\u00a0=\u00a031), KL3 (n\u00a0=\u00a067), and KL4 osteoarthritis (OA) (n\u00a0=\u00a026). Between\u2010group differences in vGRF, apGRF, and mlGRF were assessed in reference to the ACLR group throughout each percentage of stance phase using a functional linear model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ACLR group demonstrated lower vGRF and apGRF in early and late stance compared to the uninjured controls, with large effects (Cohen's <jats:italic>d<\/jats:italic> range: 1.35\u20131.66). Conversely, the ACLR group exhibited greater vGRF (87%\u201390%; 4.88% body weight [BW]; <jats:italic>d<\/jats:italic> =\u20090.75) and apGRF (84%\u201394%; 2.41% BW; <jats:italic>d<\/jats:italic> =\u20090.79) than the KL2 group in a small portion of late stance. No differences in mlGRF profiles were observed between the ACLR and either the uninjured controls or the KL2 group. The magnitude of difference in GRF profiles between the ACLR and OA groups increased with OA disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals 6 to 12 months post\u2010ACLR exhibit strikingly similar GRF profiles as individuals with KL2 KOA, suggesting both patient groups may benefit from targeted interventions to address aberrant GRF profiles.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art42744-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42744","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T03:39:43Z","timestamp":1699933183000},"page":"566-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sustained <scp>Limb\u2010Level<\/scp> Loading: A Ground Reaction Force Phenotype Common to Individuals at High Risk for and Those With Knee Osteoarthritis"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8824-9366","authenticated-orcid":false,"given":"Elizabeth","family":"Bjornsen","sequence":"first","affiliation":[{"name":"University of North Carolina at Chapel Hill  Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Berkoff","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill  Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Troy","family":"Blackburn","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill  Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope","family":"Davis\u2010Wilson","sequence":"additional","affiliation":[{"name":"RTI International  Research Triangle Park North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Evans\u2010Pickett","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill  Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Franz","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, and North Carolina State University  Raleigh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3480-3173","authenticated-orcid":false,"given":"Matthew S.","family":"Harkey","sequence":"additional","affiliation":[{"name":"Michigan State University  East Lansing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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