{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:51:00Z","timestamp":1780609860183,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Even though systemic vasculitides (SVs) affect primarily patients over 50\u2009years of age, they can occur among women of childbearing age. Preterm birth (PTB) and hypertensive disorders are frequent complications of pregnancy in SVs. This study aims to evaluate the risk of hypertensive disorders and PTB among pregnant women with SVs, and to identify associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Using the French health insurance data warehouse, we conducted a nationwide cohort study including all pregnancies between 2013 and 2018 in women with SVs. Theses pregnancies were matched to pregnancies among women without SVs. We estimated risk of hypertensive disorders and PTB risk during pregnancy among women with SVs and investigated associated risk factors using a nested case\u2010control design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 3,155,723 pregnancies, we identified 646 pregnancies in women with SVs, matched to 3,230 controls. SVs were significantly associated with hypertensive disorders (odds ratio [OR] 1.7, 95% confidence interval [95% CI] 1.3\u20132.2) and PTB (OR 1.8, 95% CI 1.4\u20132.3). Chronic renal failure before pregnancy, history of or treated arterial hypertension, the occurrence of vasculitides flare during pregnancy, and the subgroup of SVs were independently associated with the occurrence of hypertensive disorders. Maternal age at delivery, chronic renal failure before conception, and the occurrence of vasculitides flare during pregnancy were independently associated with the occurrence of PTB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>About one of seven pregnancies in women with SVs is associated with hypertensive disorders or preterm birth. The occurrence of vasculitides flare was associated with these complications. Our findings support the importance of prepregnancy counseling to ensure disease stability.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art42747-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42747","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T02:42:51Z","timestamp":1699411371000},"page":"429-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk of Hypertensive Disorders and Preterm Birth in Pregnant Women With Systemic Vasculitides: A Nationwide <scp>Population\u2010Based<\/scp> Cohort Study"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-3175","authenticated-orcid":false,"given":"Camille","family":"Mettler","sequence":"first","affiliation":[{"name":"H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-1356","authenticated-orcid":false,"given":"Nathanael","family":"Beeker","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathis","family":"Collier","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6002-8919","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Le Guern","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-7336","authenticated-orcid":false,"given":"Benjamin","family":"Terrier","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris and Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-3571","authenticated-orcid":false,"given":"Laurent","family":"Chouchana","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-020-00940-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2023.03.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.10.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-27379-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250025"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2022.103682"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.11.019"},{"issue":"4","key":"e_1_2_7_10_1","first-page":"585","article-title":"Beh\u00e7et's disease and pregnancy: a retrospective case\u2010control study","volume":"94","author":"Barros T","year":"2021","journal-title":"Yale J Biol Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.011"},{"key":"e_1_2_7_12_1","first-page":"1014","article-title":"Rheumatic diseases and pregnancy: a national survey about practice patterns among rheumatologists and obstetricians","volume":"36","author":"Fayad F","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5709"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41191"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.08.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.04.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2016.02.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13184"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05024-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.08.001"},{"key":"e_1_2_7_22_1","first-page":"94","article-title":"Polyarteritis nodosa in pregnancy","volume":"18","author":"Damian L","year":"2018","journal-title":"Ochsner J."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq421"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2023.105609"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key408"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2023.2226518"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2023.01.009"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4233"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.01.015"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2017.05.025"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.07.015"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2022.05.017"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l1964"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12326"},{"key":"e_1_2_7_35_1","unstructured":"M\u00e9thode de la cartographie des pathologies et des d\u00e9penses de l'Assurance Maladie.L'Assurance Maladie. Updated July 11 2023. Accessed August 15 2021.https:\/\/assurance\u2010maladie.ameli.fr\/etudes\u2010et\u2010donnees\/entree\u2010par\u2010theme\/pathologies\/cartographie\u2010assurance\u2010maladie\/methode\/methode\u2010cartographie\u2010pathologies\u2010depenses\u2010assurance\u2010maladie"},{"key":"e_1_2_7_36_1","unstructured":"European platform on rare disease registration.European Commission. Accessed September 28 2021.https:\/\/eu-rd-platform.jrc.ec.europa.eu"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"issue":"2","key":"e_1_2_7_38_1","first-page":"240","article-title":"The clinical use of corticosteroids in pregnancy [review]","volume":"22","author":"Kemp MW","year":"2016","journal-title":"Hum Reprod Update"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21983"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13342"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2018-0161"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X18822581"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-034145"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09250914"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez405"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.866"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60712-0"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000977"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003020"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2020.04.003"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:47:20Z","timestamp":1759945640000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.42747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,19]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/art.42747"],"URL":"https:\/\/doi.org\/10.1002\/art.42747","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,19]]},"assertion":[{"value":"2023-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}