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Moreover, in one patient with SLE who was initially classified in the SLE\u2010EB\n                      <jats:sup>lo<\/jats:sup>\n                      group, early B cell deficiency and associated abnormalities were largely rectified in a second BM sample at the remission phase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, this study suggests that early B cell loss in BM defines a unique pathological state in a subset of patients with SLE that may play an active role in the dysregulated autoimmune responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.42750","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T03:04:28Z","timestamp":1699585468000},"page":"599-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["<scp>Single\u2010Cell<\/scp>\n                    Profiling of Bone Marrow B Cells and Early B Cell Developmental Disorders Associated With Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4975-6426","authenticated-orcid":false,"given":"Chen","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Zukerman Mind Brain Behavior Institute Columbia University  New York"},{"name":"Aaron Diamond AIDS Research Center Columbia University Vagelos College of Physicians and Surgeons  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zechuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Affiliated Hospital of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghui","family":"Xue","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Medicine, Research Center of Clinical Immunology Affiliated Hospital of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Gu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China; 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