{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:22:10Z","timestamp":1791566530734,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08231"],"award-info":[{"award-number":["22K08231"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Interferon\u2010\u03bb3 (IFN\u03bb3) is a cytokine with antiviral functions on barrier surfaces, and it is associated with disease activity in autoimmune diseases. This study assessed the clinical significance of serum IFN\u03bb3 levels in polymyositis\/dermatomyositis (PM\/DM)\u2013associated interstitial lung disease (ILD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured serum IFN\u03bb3 levels in 221 patients with PM\/DM\u2010ILD (155 in the derivation cohort, 66 in the validation cohort) and 38 controls. We evaluated factors associated with mortality risk among 79 patients with anti\u2010melanoma differentiation\u2013associated gene 5 (MDA5) antibody\u2013positive DM\u2010ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum IFN\u03bb3 levels at diagnosis were significantly higher in patients with PM\/DM\u2010ILD than in healthy controls. Remarkably, serum IFN\u03bb3 levels were specifically increased in patients with anti\u2010MDA5 antibody\u2013positive DM\u2010ILD in both the derivation and validation cohorts. In anti\u2010MDA5 antibody\u2013positive DM\u2010ILD, patients with high IFN\u03bb3 levels (&gt;120 pg\/mL) had significantly lower survival rates than those with low IFN\u03bb3 levels (\u2264120 pg\/mL). A multivariate analysis revealed that high IFN\u03bb3 levels, as well as old age and low Pa<jats:sc>o<\/jats:sc><jats:sub>2<\/jats:sub>, were significantly associated with poor prognoses in patients with anti\u2010MDA5 antibody\u2013positive DM\u2010ILD. In a classification analysis of patients with anti\u2010MDA5 antibody\u2013positive DM\u2010ILD based on age, IFN\u03bb3 level, and Pa<jats:sc>o<\/jats:sc><jats:sub>2<\/jats:sub>, patients with old age (&gt;53\u2009years), high IFN\u03bb3 levels (&gt;120 pg\/mL), and low Pa<jats:sc>o<\/jats:sc><jats:sub>2<\/jats:sub> (&lt;75\u2009mm Hg) had the worst survival. In lung pathologic analyses, IFN\u03bb3\u2010positive staining was observed in macrophages, airway epithelial cells, the pleural region, and intrapulmonary veins in patients with anti\u2010MDA5 antibody\u2013positive DM\u2010ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum IFN\u03bb3 is a promising biomarker for identifying patients at high risk of poor outcomes in anti\u2010MDA5 antibody\u2013positive DM\u2010ILD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42785","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:34:12Z","timestamp":1703550852000},"page":"796-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prognostic Role of Interferon\u2010\u03bb3 in Anti\u2013Melanoma Differentiation\u2013Associated Gene 5\u2013Positive <scp>Dermatomyositis\u2010Associated<\/scp> Interstitial Lung Disease"],"prefix":"10.1002","volume":"76","author":[{"given":"Atsuki","family":"Fukada","sequence":"first","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-1781","authenticated-orcid":false,"given":"Tomoyuki","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-1543","authenticated-orcid":false,"given":"Hironao","family":"Hozumi","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Koda","sequence":"additional","affiliation":[{"name":"Hamamatsu Rosai Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Shizuoka General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Oyama","sequence":"additional","affiliation":[{"name":"Shizuoka Saiseikai General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuomi","family":"Satake","sequence":"additional","affiliation":[{"name":"Shizuoka City Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Niwa","sequence":"additional","affiliation":[{"name":"Hamamatsu Medical Center  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kaida","sequence":"additional","affiliation":[{"name":"Enshu Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshi","family":"Yokomura","sequence":"additional","affiliation":[{"name":"Seirei Mikatahara General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Koshimizu","sequence":"additional","affiliation":[{"name":"Fujieda Municipal General Hospital  Fujieda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Hamamatsu Rosai Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Imokawa","sequence":"additional","affiliation":[{"name":"Iwata City Hospital  Iwata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Nippon Medical School Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-1771","authenticated-orcid":false,"given":"Takahisa","family":"Gono","sequence":"additional","affiliation":[{"name":"Nippon Medical School Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-6136","authenticated-orcid":false,"given":"Masataka","family":"Kuwana","sequence":"additional","affiliation":[{"name":"Nippon Medical School Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Yamano","sequence":"additional","affiliation":[{"name":"Tosei General Hospital  Seto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kondoh","sequence":"additional","affiliation":[{"name":"Tosei General Hospital  Seto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Mori","sequence":"additional","affiliation":[{"name":"Shizuoka City Shimizu Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-0597","authenticated-orcid":false,"given":"Yusuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Yasui","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Karayama","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Furuhashi","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-4264","authenticated-orcid":false,"given":"Noriyuki","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Inui","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Suda","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40320"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"58","article-title":"Differences in clinical features and prognosis of interstitial lung diseases between polymyositis and dermatomyositis","volume":"32","author":"Fujisawa T","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30513"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098824"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00002015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316651748"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.10.019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key060"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57040347"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41566"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120313"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21023"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes102"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.01.014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009727"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190295"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0182-z"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.87"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00606-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000581"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50709-9"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.145145"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13978"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00038806"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180825"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez185"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1023-2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1683-z"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800147"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc3545"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu258"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key386"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez301"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab371"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01618-2020"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102666"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.773352"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:27:33Z","timestamp":1759940853000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.42785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/art.42785"],"URL":"https:\/\/doi.org\/10.1002\/art.42785","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"assertion":[{"value":"2023-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}