{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:14:07Z","timestamp":1791591247921,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["115565"],"award-info":[{"award-number":["115565"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007\u20132013"],"award-info":[{"award-number":["FP7\/2007\u20132013"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"\n Objective<\/jats:title>\n The biologic diagnosis of primary Sj\u00f6gren disease (SjD) mainly relies on anti\u2010Ro60\/SSA antibodies, whereas the significance of anti\u2010Ro52\/TRIM21 antibodies currently remains unclear. The aim of this study was to characterize the clinical, serological, biologic, transcriptomic, and interferon profiles of patients with SjD according to their anti\u2010Ro52\/TRIM21 antibody status.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with SjD from the European PRECISESADS (n\u00a0=\u00a0376) and the Brittany Diagnostic Suspicion of primitive Sj\u00f6gren's Syndrome (DIApSS); (n\u00a0=\u00a0146) cohorts were divided into four groups: double negative (Ro52\n \u2212<\/jats:sup>\n \/Ro60\n \u2212<\/jats:sup>\n ), isolated anti\u2010Ro52\/TRIM21 positive (Ro52\n +<\/jats:sup>\n ), isolated anti\u2010Ro60\/SSA positive (Ro60\n +<\/jats:sup>\n ), and double\u2010positive (Ro52\n +<\/jats:sup>\n \/Ro60\n +<\/jats:sup>\n ) patients. Clinical information; EULAR Sj\u00f6gren Syndrome Disease Activity Index, a score representing systemic activity; and biologic markers associated with disease severity were evaluated. Transcriptome data obtained from whole blood by RNA sequencing and type I and II interferon signatures were analyzed for PRECISESADS patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the DIApSS cohort, Ro52\n +<\/jats:sup>\n \/Ro60\n +<\/jats:sup>\n patients showed significantly more parotidomegaly (33.3% vs 0%\u201311%) along with higher \u03b22\u2010microglobulin (\n P<\/jats:italic>\n =\u20090.0002), total immunoglobulin (\n P<\/jats:italic>\n <\u20090.0001), and erythrocyte sedimentation rate levels (\n P<\/jats:italic>\n =\u20090.002) as well as rheumatoid factor (RF) positivity (66.2% vs 20.8%\u201325%) compared to other groups. The PRECISESADS cohort corroborated these observations, with increased arthritis (\n P<\/jats:italic>\n =\u20090.046), inflammation (\n P<\/jats:italic>\n =\u20090.005), hypergammaglobulinemia (\n P<\/jats:italic>\n <\u20090.0001), positive RF (\n P<\/jats:italic>\n <\u20090.0001), leukopenia (\n P<\/jats:italic>\n =\u20090.004), and lymphopenia (\n P<\/jats:italic>\n =\u20090.009) in Ro52\n +<\/jats:sup>\n \/Ro60\n +<\/jats:sup>\n patients. Cumulative EULAR Sj\u00f6gren Syndrome Disease Activity Index results further confirmed these disparities (\n P<\/jats:italic>\n =\u20090.002). Transcriptome analysis linked anti\u2010Ro52\/TRIM21 antibody positivity to interferon pathway activation as an underlying cause for these clinical correlations.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These results suggest that the combination of anti\u2010Ro52\/TRIM21 and anti\u2010Ro60\/SSA antibodies is associated with a clinical, biologic, and transcriptional profile linked to greater disease severity in SjD through the potentiation of the interferon pathway activation by anti\u2010Ro52\/TRIM21 antibodies.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.42789","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:54:46Z","timestamp":1703206486000},"page":"751-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Association of Combined\n Anti\u2010Ro52<\/scp>\n \/\n TRIM21<\/scp>\n and\n Anti\u2010Ro60<\/scp>\n \/\n SSA<\/scp>\n Antibodies With Increased Sj\u00f6gren Disease Severity Through Interferon Pathway Activation"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0797-8098","authenticated-orcid":false,"given":"El\u00e9onore","family":"Bettacchioli","sequence":"first","affiliation":[{"name":"LBAI, UMR1227, INSERM, University of Western Brittany, Brest, France, and Centre Hospitalier Universitaire de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-7067","authenticated-orcid":false,"given":"Alain","family":"Saraux","sequence":"additional","affiliation":[{"name":"LBAI, UMR1227, INSERM, University of Western Brittany, Brest, France, and Centre Hospitalier Universitaire de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Tison","sequence":"additional","affiliation":[{"name":"LBAI, UMR1227, INSERM, University of Western Brittany, Brest, France, and Centre Hospitalier Universitaire de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-702X","authenticated-orcid":false,"given":"Divi","family":"Cornec","sequence":"additional","affiliation":[{"name":"LBAI, UMR1227, INSERM, University of Western Brittany, Brest, France, and Centre Hospitalier Universitaire de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryvonne","family":"Dueymes","sequence":"additional","affiliation":[{"name":"LBAI, UMR1227, INSERM, University of Western Brittany, Brest, France, and Centre Hospitalier Universitaire de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Foulquier","sequence":"additional","affiliation":[{"name":"LBAI, UMR1227, INSERM, University of Western Brittany, Brest, France, and Centre Hospitalier Universitaire de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-0981","authenticated-orcid":false,"given":"Sophie","family":"Hillion","sequence":"additional","affiliation":[{"name":"LBAI, UMR1227, INSERM, University of Western Brittany, Brest, France, and Centre Hospitalier Universitaire de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Roguedas\u2010Contios","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas\u2010Alexis","family":"Benyoussef","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta E.","family":"Alarcon\u2010Riquelme","sequence":"additional","affiliation":[{"name":"Center for Genomics and Oncological Research Granada 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