{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:56:49Z","timestamp":1787965009008,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001275","name":"Oak Foundation","doi-asserted-by":"publisher","award":["OCAY\u201018\u2010774\u2010OFIL"],"award-info":[{"award-number":["OCAY\u201018\u2010774\u2010OFIL"]}],"id":[{"id":"10.13039\/100001275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite scarce evidence, guidelines recommend weight loss as a management strategy for patients with gout. We investigated the effect of an intensive dietary intervention on body weight and clinical measures of gout severity in individuals with obesity and gout.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a 16\u2010week randomized nonmasked parallel\u2010group trial in Denmark, randomly assigning (one\u2010to\u2010one) individuals with obesity and gout to a low\u2010energy diet or a control diet. The primary outcome was change in body weight. Key secondary outcomes were changes in serum urate (SU) level and visual analog scale\u2013assessed pain and fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between December 1, 2018, and June 1, 2019, 61 participants were included in the intention\u2010to\u2010treat population and randomly assigned to the intensive diet group (n\u00a0=\u00a029) or control diet group (n\u00a0=\u00a032). Participants had a mean age of 60.3 (SD 9.9) years and mean body mass index of 35.6 (SD 5.0), and 59 (97%) were men. After 16\u2009weeks, there was a significant difference in change in body weight between the diet and control groups (\u221215.4 vs \u22127.7 kg; difference \u22127.7 kg [95% confidence interval \u221210.7 to \u22124.7], <jats:italic>P<\/jats:italic> &lt;\u20090.001). Despite results being potentially in favor of a low\u2010energy diet, we could not confirm differences in SU level changes and fatigue between groups. No differences in pain and gout flares were observed between groups. No serious adverse events or deaths occurred during the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An intensive dietary intervention was safe and effectively lowered body weight in people with obesity and gout, but the weight loss did not directly translate into effects on SU level, fatigue, and pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42790","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T21:44:25Z","timestamp":1704231865000},"page":"806-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Weight Loss for Patients With Gout and Concomitant Obesity: A <scp>Proof\u2010of\u2010Concept<\/scp> Randomized Trial"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6600-0631","authenticated-orcid":false,"given":"Robin","family":"Christensen","sequence":"first","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark, and University of Southern Denmark, Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6508-5039","authenticated-orcid":false,"given":"Kristian","family":"Zobbe","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina M.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark, and University of Southern Denmark, Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-2912","authenticated-orcid":false,"given":"Lisa K.","family":"Stamp","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Otago, Christchurch  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-2962","authenticated-orcid":false,"given":"Marius","family":"Henriksen","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders F.","family":"Overgaard","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Aalborg University Hospital, Aalborg, Denmark, and University of Aalborg  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark, Steno Diabetes Center Copenhagen, and Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-0006","authenticated-orcid":false,"given":"Jasvinder A.","family":"Singh","sequence":"additional","affiliation":[{"name":"Medicine Service, VA Medical Center, Birmingham, School of Medicine, University of Alabama at Birmingham (UAB), and UAB School of Public Health  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Doherty","sequence":"additional","affiliation":[{"name":"Academic Rheumatology, School of Medicine, University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Richette","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Lariboisi\u00e8re APHP Paris Nord and Universit\u00e9 de Paris, INSERM, UMR\u2010S 1132  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Astrup","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-3597","authenticated-orcid":false,"given":"Karen","family":"Ellegaard","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else M.","family":"Bartels","sequence":"additional","affiliation":[{"name":"The Parker Institute, and Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Boesen","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Gudbergsen","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7951-1668","authenticated-orcid":false,"given":"Henning","family":"Bliddal","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Erik","family":"Kristensen","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30520"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209707"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00346-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001124"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.7.539"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92271-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211472"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-7-200510040-00009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203325"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22504"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-11-201006010-00232"},{"key":"e_1_2_6_13_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2020"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_6_15_1","unstructured":"emmeans. Version 1.9.emmeans: estimated marginal means aka least\u2010squares mean.2020.https:\/\/cran.r-project.org\/package=emmeans."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11121"},{"issue":"0","key":"e_1_2_6_17_1","first-page":"1","article-title":"2020 American College of Rheumatology guideline for the management of gout","volume":"0","author":"FitzGerald JD","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203970"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12949"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:27:37Z","timestamp":1759940857000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.42790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/art.42790"],"URL":"https:\/\/doi.org\/10.1002\/art.42790","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]},"assertion":[{"value":"2023-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}