{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:20:49Z","timestamp":1793164849899,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K08734"],"award-info":[{"award-number":["17K08734"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07384"],"award-info":[{"award-number":["20K07384"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we examine how advancements in novel antirheumatic drugs affect the clinicopathologic features of lymphoproliferative disorder (LPD) in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter study across 53 hospitals in Japan, we characterized patients with RA who developed LPDs and visited the hospitals between January 1999 and March 2021. The statistical tools used included Fisher's exact test, the Mann\u2010Whitney <jats:italic>U<\/jats:italic>\u2010test, the log\u2010rank test, logistic regression analysis, and Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 752 patients with RA\u2010associated LPD (RA\u2010LPD) and 770 with sporadic LPD were included in the study. We observed significant differences in the clinicopathologic features between patients with RA\u2010LPD and those with sporadic LPD. Histopathological analysis revealed a high frequency of LPD\u2010associated immunosuppressive conditions. Furthermore, patients with RA\u2010LPD were evaluated based on the antirheumatic drugs administered. The methotrexate (MTX) plus tacrolimus and MTX plus tumor necrosis factor inhibitor (TNFi) groups had different affected site frequencies and histologic subtypes than the MTX\u2010only group. Moreover, MTX and TNFi may synergistically affect susceptibility to Epstein\u2010Barr virus infection. In case of antirheumatic drugs administered after LPD onset, tocilizumab (TCZ)\u2013only therapy was associated with lower frequency of regrowth after spontaneous regression than other regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antirheumatic drugs administered before LPD onset may influence the clinicopathologic features of RA\u2010LPD, with patterns changing over time. Furthermore, TCZ\u2010only regimens are recommended after LPD onset.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art42809-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42809","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T21:59:17Z","timestamp":1706219957000},"page":"869-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Recent Antirheumatic Drug on Features of Rheumatoid Arthritis\u2013Associated Lymphoproliferative Disorders"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3166-9754","authenticated-orcid":false,"given":"Yoshihiko","family":"Hoshida","sequence":"first","affiliation":[{"name":"National Health Organization (NHO) Osaka Minami Medical Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Tsujii","sequence":"additional","affiliation":[{"name":"National Health Organization (NHO) Osaka Minami Medical Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Ohshima","sequence":"additional","affiliation":[{"name":"National Health Organization (NHO) Osaka Minami Medical Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3870-0275","authenticated-orcid":false,"given":"Yukihiko","family":"Saeki","sequence":"additional","affiliation":[{"name":"National Health Organization (NHO) Osaka Minami Medical 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