{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:41:18Z","timestamp":1790631678560,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007496","name":"VA Biomedical Laboratory Research and Development","doi-asserted-by":"publisher","award":["BX004660"],"award-info":[{"award-number":["BX004660"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["PR200793"],"award-info":[{"award-number":["PR200793"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54 GM115458"],"award-info":[{"award-number":["U54 GM115458"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019637","name":"Horizon Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the associations of plasma matrix metalloproteinases (MMPs) with prevalent and incident interstitial lung disease (ILD) in people with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within a multicenter, prospective cohort of US veterans with RA, we performed a cross\u2010sectional study of prevalent ILD and cohort study of incident ILD. ILD diagnoses were validated by medical record review of provider diagnoses and chest imaging and\/or pathology reports. MMP\u20101, 3, 7, and 9 concentrations were measured in plasma samples, then standardized and categorized into quartiles. The associations of MMPs with prevalent and incident ILD were assessed with logistic (prevalent) and Cox (incident) regression models adjusted for RA\u2010ILD risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2,312 participants (88.9% male; mean age 63.8\u2009years), 96 had prevalent ILD. Incident ILD developed in 130 participants over 17,378 person\u2010years of follow\u2010up (crude incidence rate 7.5\/1,000 person\u2010years). Participants with the highest quartile of MMP\u20107 concentrations had a nearly four\u2010fold increased odds of prevalent ILD (adjusted odds ratio 3.78 [95% confidence interval (95% CI) 1.86\u20137.65]) and over two\u2010fold increased risk of incident ILD (adjusted hazard ratio 2.33 [95% CI 1.35\u20134.02]). Higher MMP\u20109 concentrations were also associated with prevalent and incident ILD, as well as negatively correlated with forced vital capacity among those with prevalent ILD (<jats:italic>r<\/jats:italic> = \u22120.30, <jats:italic>P<\/jats:italic> =\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MMP\u20107 and MMP\u20109 were strongly associated with both prevalent and incident ILD in this large, multicenter RA cohort after adjustment for other RA\u2010ILD risk factors. These population\u2010level findings further support a potential pathogenic role for MMPs in RA\u2010ILD and suggest that their measurement could facilitate RA\u2010ILD risk stratification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42812","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T03:44:48Z","timestamp":1706154288000},"page":"1013-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Plasma Matrix Metalloproteinase Concentrations and Risk of Interstitial Lung Disease in a Prospective Rheumatoid Arthritis Cohort"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-9680","authenticated-orcid":false,"given":"Brent A.","family":"Luedders","sequence":"first","affiliation":[{"name":"VA Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8816-7782","authenticated-orcid":false,"given":"Austin M.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"VA Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1387-0860","authenticated-orcid":false,"given":"Dana P.","family":"Ascherman","sequence":"additional","affiliation":[{"name":"Pittsburgh VA and University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center and University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Duryee","sequence":"additional","affiliation":[{"name":"VA Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyuna","family":"Yang","sequence":"additional","affiliation":[{"name":"VA Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punyasha","family":"Roul","sequence":"additional","affiliation":[{"name":"VA Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-7649","authenticated-orcid":false,"given":"Katherine D.","family":"Wysham","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System and University of Washington  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4937-0515","authenticated-orcid":false,"given":"Paul","family":"Monach","sequence":"additional","affiliation":[{"name":"Boston VA Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reimold","sequence":"additional","affiliation":[{"name":"Dallas VA and University of Texas Southwestern  Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail S.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Washington, DC VA, Howard University, and Georgetown University  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Kunkel","sequence":"additional","affiliation":[{"name":"VA Salt Lake City Health Care System and University of Utah  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-9173","authenticated-orcid":false,"given":"Grant W.","family":"Cannon","sequence":"additional","affiliation":[{"name":"VA Salt Lake City Health Care System and University of Utah  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-2563","authenticated-orcid":false,"given":"Jill A.","family":"Poole","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Thiele","sequence":"additional","affiliation":[{"name":"VA Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-2272","authenticated-orcid":false,"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[{"name":"VA Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-3588","authenticated-orcid":false,"given":"Bryant R.","family":"England","sequence":"additional","affiliation":[{"name":"VA Nebraska\u2010Western Iowa Health Care System and University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27405"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez177"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24856"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac208"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202006-590OC"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu165"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801562"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11535"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.200863"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146510"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.6.455"},{"issue":"5","key":"e_1_2_6_13_1","first-page":"644","article-title":"Pannus invasion and cartilage degradation in rheumatoid arthritis: involvement of MMP\u20103 and interleukin\u20101beta","volume":"23","author":"Ainola MM","year":"2005","journal-title":"Clin Exp Rheumatol"},{"issue":"6","key":"e_1_2_6_14_1","first-page":"3048","article-title":"Immunolocalization of MMP\u20102 and MMP\u20109 in human rheumatoid synovium","volume":"7","author":"Zhou M","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/179284"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)44:10<2263::AID-ART389>3.0.CO;2-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.11.1094"},{"issue":"12","key":"e_1_2_6_18_1","first-page":"2761","article-title":"Serum matrix metalloproteinase 3 in early rheumatoid arthritis is correlated with disease activity and radiological progression","volume":"27","author":"Posthumus MD","year":"2000","journal-title":"J Rheumatol"},{"issue":"2","key":"e_1_2_6_19_1","first-page":"251","article-title":"Circulating levels of matrix metalloproteinases MMP\u20103 and MMP\u20101, tissue inhibitor of metalloproteinases 1 (TIMP\u20101), and MMP\u20101\/TIMP\u20101 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers","volume":"26","author":"Keyszer G","year":"1999","journal-title":"J Rheumatol."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050093"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12920"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00074-2016"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01612-2021"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01321.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01560-2021"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41123"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38904"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201411-1950OC"},{"issue":"5","key":"e_1_2_6_29_1","first-page":"24","article-title":"Insights and implications of the VA Rheumatoid Arthritis Registry","volume":"32","author":"Mikuls TR","year":"2015","journal-title":"Fed Pract."},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2021.113048"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.159608"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140164"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20629"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.152098"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40900"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104591"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88734-2"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107465"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)44:10<2235::AID-ART385>3.0.CO;2-A"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400510"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-2-199501150-00001"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42812","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:54:30Z","timestamp":1759953270000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.42812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/art.42812"],"URL":"https:\/\/doi.org\/10.1002\/art.42812","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,15]]},"assertion":[{"value":"2023-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}