{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:57:47Z","timestamp":1788976667553,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["ZIA\u2010AR\u2010041203"],"award-info":[{"award-number":["ZIA\u2010AR\u2010041203"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ZIA\u2010ES\u2010101074"],"award-info":[{"award-number":["ZIA\u2010ES\u2010101074"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ZIA\u2010ES\u2010101081"],"award-info":[{"award-number":["ZIA\u2010ES\u2010101081"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Myositis\u2010associated autoantibodies (MAAs) have been associated with overlap myositis, certain disease manifestations such as interstitial lung disease (ILD), and worse prognosis in the idiopathic inflammatory myopathies. MAAs overall remain largely uncharacterized in patients with juvenile\u2010onset myositis. Moreover, it is unknown whether the number of MAAs is associated with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with juvenile myositis in cross\u2010sectional natural history studies who underwent testing for myositis autoantibodies were included. Demographics, myositis autoantibodies, clinical characteristics, medications received, and outcomes of those with and without MAAs were compared. Multivariable logistic regression was performed to determine whether the number of MAAs detected was associated with severe disease features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 551 patients, 36% had an MAA and 13% had more than one MAA. Among those who were MAA positive, there was a higher frequency of overlap myositis (18% vs 5.9%, <jats:italic>P<\/jats:italic> &lt;\u20090.001). MAA positivity was associated with certain clinical features, including Raynaud phenomenon (odds ratio [OR] 2.44, 95% confidence interval [CI] 1.41\u20134.28) and ILD (OR 3.43, 95% CI 1.75\u20136.96), as well as a chronic disease course (OR 1.72, 95% CI 1.10\u20132.72) and mortality (OR 3.76, 95% CI 1.72\u20138.43). The number of MAAs was also associated with mortality (OR 1.83, 95% CI 1.16\u20132.86).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MAAs were prevalent in a large cohort of patients with juvenile myositis. ILD, refractory disease, and mortality were associated with MAA positivity. Prospective studies are needed to determine whether early detection of MAAs may lead to improved outcomes for patients with juvenile myositis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42813","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T22:35:23Z","timestamp":1706222123000},"page":"963-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>Myositis\u2010Associated<\/scp> Autoantibodies in Patients With Juvenile Myositis Are Associated With Refractory Disease and Mortality"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-1538","authenticated-orcid":false,"given":"Matthew A.","family":"Sherman","sequence":"first","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Noroozi Farhadi","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences NIH  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Pak","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P.","family":"Trieu","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation  Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kakali","family":"Sarkar","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences NIH  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira N.","family":"Targoff","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research Foundation  Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Neely","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-3252","authenticated-orcid":false,"given":"Andrew L.","family":"Mammen","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, and Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-2458","authenticated-orcid":false,"given":"Lisa G.","family":"Rider","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences NIH  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Childhood Myositis Heterogeneity Collaborative Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.56"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00321-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212436"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-215004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.06.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31829d08f9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40320"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/15027732.1986.12461374","article-title":"First international symposium on Sjogren's syndrome: suggested criteria for classification","volume":"61","author":"Fox RI","year":"1986","journal-title":"Scand J Rheumatol Suppl"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31827f264d"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa371"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20071"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209247"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac115"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23113"},{"key":"e_1_2_7_22_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_7_23_1","volume-title":"An R Companion to Applied Regression","author":"Fox J","year":"2019"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_2_7_25_1","volume-title":"ggpubr: \u2018ggplot2\u2019 Based Publication Ready Plots","author":"Kassambara A.","year":"2020"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2021-053"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx364"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22212"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005638"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09484.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.04.001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01334.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007188"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24167"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20015"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq261"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/h0s7tq"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.09.008"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.220139"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.6285"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2426"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.116384"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203160"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001278"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41140"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-12-0839"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.04.009"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035296"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2022-000732"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12449"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21031"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42243"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel099"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-022-00709-3"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:46:45Z","timestamp":1759924005000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.42813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,12]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/art.42813"],"URL":"https:\/\/doi.org\/10.1002\/art.42813","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,12]]},"assertion":[{"value":"2023-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}