{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:48:10Z","timestamp":1790196490520,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM130423"],"award-info":[{"award-number":["P20GM130423"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54GM115458"],"award-info":[{"award-number":["U54GM115458"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR200793"],"award-info":[{"award-number":["PR200793"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to determine the associations of protein\u2010specific anti\u2013malondialdehyde\u2010acetaldehyde (MAA) antibodies with prevalent and incident rheumatoid arthritis\u2013interstitial lung disease (RA\u2010ILD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within a multicenter, prospective cohort of US veterans with RA, RA\u2010ILD was validated by medical record review of clinical diagnoses, chest imaging, and pathology. Serum antibodies to MAA\u2010albumin, MAA\u2010collagen, MAA\u2010fibrinogen, and MAA\u2010vimentin (IgA, IgM, and IgG) were measured by a standardized enzyme\u2010linked immunosorbent assay. Associations of anti\u2010MAA antibodies with prevalent and incident RA\u2010ILD were assessed using multivariable regression models adjusting for established RA\u2010ILD risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2,739 participants with RA (88% male, mean age of 64 years), there were 114 with prevalent and 136 with incident RA\u2010ILD (average time to diagnosis: 6.6 years). Higher IgM anti\u2013MAA\u2010collagen (per 1 SD: adjusted odds ratio [aOR] 1.28, 95% confidence interval [CI] 1.02\u20131.61), IgA anti\u2013MAA\u2010fibrinogen (aOR 1.48, 95% CI 1.14\u20131.92), and IgA (aOR 1.78, 95% CI 1.34\u20132.37) and IgG (aOR 1.48, 95% CI 1.14\u20131.92) anti\u2013MAA\u2010vimentin antibodies were associated with prevalent RA\u2010ILD. In incident analyses, higher IgA (per one SD: adjusted hazards ratio [aHR] 1.40, 95% CI 1.11\u20131.76) and IgM (aHR 1.29, 95% CI 1.04\u20131.60) anti\u2013MAA\u2010albumin antibody concentrations were associated with increased ILD risk. Participants with IgA (aHR 2.13, 95% CI 1.16\u20133.90) or IgM (aHR 1.98, 95% CI 1.08\u20133.64) anti\u2013MAA\u2010albumin antibody concentrations in the highest quartile had an approximately two\u2010fold increased risk of incident RA\u2010ILD. Across all isotypes, anti\u2013MAA\u2010fibrinogen, anti\u2013MAA\u2010collagen, and anti\u2013MAA\u2010vimentin antibodies were not significantly associated with incident RA\u2010ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Protein\u2010specific anti\u2010MAA antibodies to collagen, fibrinogen, and vimentin were associated with prevalent RA\u2010ILD. IgA and IgM anti\u2013MAA\u2010albumin antibodies were associated with a higher risk of incident RA\u2010ILD. These findings suggest that MAA modifications and resultant immune responses may contribute to RA\u2010ILD pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42916","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T04:13:11Z","timestamp":1716178391000},"page":"1353-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antibodies to Malondialdehyde\u2010Acetaldehyde Adduct Are Associated With Prevalent and Incident Rheumatoid Arthritis\u2013Associated Interstitial Lung Disease in <scp>US<\/scp> Veterans"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-8807","authenticated-orcid":false,"given":"Nozima","family":"Aripova","sequence":"first","affiliation":[{"name":"University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Thiele","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and Veterans Affairs Nebraska\u2014Western Iowa Health Care System  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Duryee","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and Veterans Affairs Nebraska\u2014Western Iowa Health Care System  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D.","family":"Hunter","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and Veterans Affairs Nebraska\u2014Western Iowa Health Care System  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyuna","family":"Yang","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and Veterans Affairs Nebraska\u2014Western Iowa Health Care System  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punyasha","family":"Roul","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and Veterans Affairs Nebraska\u2014Western Iowa Health Care System  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1387-0860","authenticated-orcid":false,"given":"Dana P.","family":"Ascherman","sequence":"additional","affiliation":[{"name":"Pittsburgh Veterans Affairs and University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Matson","sequence":"additional","affiliation":[{"name":"University of Kansas  Kansas City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Kunkel","sequence":"additional","affiliation":[{"name":"University of Utah and Veterans Affairs Salt Lake City Health Care System  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-9173","authenticated-orcid":false,"given":"Grant W.","family":"Cannon","sequence":"additional","affiliation":[{"name":"University of Utah and Veterans Affairs Salt Lake City Health Care System  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-7649","authenticated-orcid":false,"given":"Katherine D.","family":"Wysham","sequence":"additional","affiliation":[{"name":"Veterans Affairs Puget Sound Health Care System and University of Washington  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-3235","authenticated-orcid":false,"given":"Gail S.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Washington D.C. Veterans Affairs Medical Center, Georgetown and Howard University Hospitals"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4937-0515","authenticated-orcid":false,"given":"Paul A.","family":"Monach","sequence":"additional","affiliation":[{"name":"Boston Veterans Affairs Health Care System  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-7563","authenticated-orcid":false,"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz Veterans Affairs and University of Pennsylvania, Perelman School of Medicine  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-2563","authenticated-orcid":false,"given":"Jill A.","family":"Poole","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-2272","authenticated-orcid":false,"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and Veterans Affairs Nebraska\u2014Western Iowa Health Care System  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-3588","authenticated-orcid":false,"given":"Bryant R.","family":"England","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and Veterans Affairs Nebraska\u2014Western Iowa Health Care System  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27405"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201004-0622OC"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171315"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211138"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22752"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25053"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11535"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/726598"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24827"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05808-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202006-590OC"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37881"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2019.01.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216709"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40900"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02696"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42812"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801562"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.152098"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.044743"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22817"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-006-0498-y"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead260"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001278"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204912"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2751"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28756"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38201"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex212"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106433"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38969"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02085-8"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3745"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108069"},{"key":"e_1_2_6_36_1","first-page":"24","article-title":"Insights and implications of the VA Rheumatoid Arthritis Registry","volume":"32","author":"Mikuls TR","year":"2015","journal-title":"Fed Pract"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109010"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23579"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20629"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24043"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac208"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203160"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(22)00380-0"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1203548"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5926-2-S1-S25"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035296"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41424"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.08.001"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000469"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42916","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:36:25Z","timestamp":1759952185000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.42916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,8]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/art.42916"],"URL":"https:\/\/doi.org\/10.1002\/art.42916","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,8]]},"assertion":[{"value":"2023-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}