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Participants underwent clinical, ultrasonographic, and MSOT examination of six entheses (lateral humeral epicondyle, distal patellar tendon attachment, and Achilles tendon attachment). MSOT\u2010measured hemoglobin (Hb), oxygen saturation (SO<jats:sub>2<\/jats:sub>), collagen, and lipid levels were quantified, and mean differences between groups were calculated using linear mixed effects models. MSOT\u2010measured analytes were compared between entheses with and without clinical and ultrasound anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety participants were included (30 PsO, 30 PsA, and 30 HCs), 540 entheses were clinically assessed, and 540 ultrasound and 830 MSOT scans were obtained. Patients with PsA and PsO showed increased oxygenated Hb (PsA: <jats:italic>P<\/jats:italic> = 0.003; PsO: <jats:italic>P<\/jats:italic> = 0.054) and SO<jats:sub>2<\/jats:sub> (PsA: <jats:italic>P<\/jats:italic> &lt; 0.001; PsO: <jats:italic>P<\/jats:italic> = 0.001) levels and decreased collagen signals (PsA: <jats:italic>P<\/jats:italic> &lt; 0.001; PsO: <jats:italic>P<\/jats:italic> &lt; 0.001) compared with HCs, with more pronounced changes in PsA. Significantly lower collagen levels (<jats:italic>P<\/jats:italic> = 0.01) and increased lipids (<jats:italic>P<\/jats:italic> = 0.03) were recorded in tender entheses compared with nontender ones. Erosions and enthesophytes on ultrasound were associated with significant differences in SO<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic> = 0.014) and lipid signals (<jats:italic>P<\/jats:italic> = 0.020), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with PsA and PsO exhibit an analogous metabolic pattern at the entheses that is exacerbated in the presence of inflammation. These findings support the notion of a psoriatic disease spectrum characterized by common immunometabolic tissue changes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42917","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T01:28:07Z","timestamp":1715822887000},"page":"1387-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Unveiling Metabolic Similarities of Entheses in Patients with Psoriasis and Psoriatic Arthritis Using Noninvasive In Vivo Molecular Imaging: Results From a Cross\u2010sectional Exploratory Study"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6122-0774","authenticated-orcid":false,"given":"Filippo","family":"Fagni","sequence":"first","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen 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Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2026-7728","authenticated-orcid":false,"given":"Arnd","family":"Kleyer","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sticherling","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Regensburger","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander University Erlangen\u2010Nuremberg and Universit\u00e4tsklinikum Erlangen  Erlangen 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