{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:55:31Z","timestamp":1781880931142,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["3052242\/2019"],"award-info":[{"award-number":["3052242\/2019"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303422\/2015\u20107"],"award-info":[{"award-number":["303422\/2015\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303116\/2022\u20106"],"award-info":[{"award-number":["303116\/2022\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/03765\u20104"],"award-info":[{"award-number":["2015\/03765\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/17272\u20100"],"award-info":[{"award-number":["2019\/17272\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the influence of anti\u2010infliximab (IFX) antibodies on three different points of care: response\/tolerance to IFX, tapering strategy, and in a subsequent treatment with a second tumor necrosis factor inhibitor (TNFi).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort of 60 patients with radiographic axial spondyloarthritis who received IFX were evaluated retrospectively regarding clinical\/laboratorial data, IFX levels, and anti\u2010IFX antibodies at baseline, after 6, 12 to 14, 22 to 24, 48 to 54, 96 to 102 weeks, and before tapering or switching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010IFX antibodies were detected in 27 patients (45%), of whom 23 (85.1%) became positive in the first year of IFX treatment. In comparison to the group that was negative for anti\u2010IFX antibodies, patients who were positive for anti\u2010IFX antibodies demonstrated the following: less use of methotrexate as a concomitant treatment to IFX (5 [18.5%] vs 14 [42.4%]; <jats:italic>P<\/jats:italic> = 0.048), more infusion reactions at 22 to 24 weeks (<jats:italic>P<\/jats:italic> = 0.020) and 48 to 54 weeks (<jats:italic>P<\/jats:italic> = 0.034), more treatment failures (<jats:italic>P<\/jats:italic> = 0.028) at 48 to 54 weeks, reduced overall IFX survival (<jats:italic>P<\/jats:italic> &lt; 0.001), and lower sustained responses (<jats:italic>P<\/jats:italic> = 0.044). Of note, patients who were positive for anti\u2010IFX antibodies exhibited a shorter tapering survival (9.9 months [95% confidence interval (CI) 4.0\u201315.8] vs 63.4 months [95% CI 27.9\u201398.8]; <jats:italic>P<\/jats:italic> = 0.004) in comparison with patients who were negative for anti\u2010IFX antibodies. Conversely, for patients who failed IFX, patients who were positive for anti\u2010IFX antibodies had better clinical response to the second TNFi at three months (15 [83.3%] vs 3 [27.3%]; <jats:italic>P<\/jats:italic> = 0.005) and six months (15 [83.3%] vs 4 [36.4%]; <jats:italic>P<\/jats:italic> = 0.017) than the patients who were negative for anti\u2010IFX antibodies after switching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provided novel data that anti\u2010IFX antibodies is a parameter for reduced tapering survival, reinforcing its detection to guide clinical decision. Additionally, we confirmed in a long\u2010term cohort the anti\u2010IFX antibody association with worse IFX performance and as predictor of the second TNFi good clinical response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.42923","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T08:03:45Z","timestamp":1716797025000},"page":"1488-1500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010Term Follow\u2010Up of Anti\u2010Infliximab Antibodies in Patients With Radiographic Axial Spondyloarthritis: A Marker of Drug Survival and Tapering"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-4734","authenticated-orcid":false,"given":"Clarissa Q.","family":"Pimentel","sequence":"first","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-5906","authenticated-orcid":false,"given":"Ana Cristina","family":"Medeiros\u2010Ribeiro","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Y.","family":"Shimabuco","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9843-6686","authenticated-orcid":false,"given":"Percival D.","family":"Sampaio\u2010Barros","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falio C\u00e9sar B.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia G.","family":"Schainberg","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celio Roberto","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine P.","family":"Leon","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9onard De Vinci K.","family":"Kupa","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra G.","family":"Pasoto","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7585-4348","authenticated-orcid":false,"given":"N\u00e1dia E.","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Instituto da Crian\u00e7a e do Adolescente Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clovis A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Instituto da Crian\u00e7a e do Adolescente Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-4681","authenticated-orcid":false,"given":"Eloisa","family":"Bonfa","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9720-0719","authenticated-orcid":false,"given":"Carla G. S.","family":"Saad","sequence":"additional","affiliation":[{"name":"Rheumatology Division Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205322"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-020-0116-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-023-00324-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223296"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202545"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.072397"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1360280"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202220"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.406"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12093271"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00540-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8140-3"},{"issue":"2","key":"e_1_2_6_15_1","first-page":"228","article-title":"The prevalence and clinical effect of immunogenicity of TNF\u2010\u03b1 blockers in patients with axial spondyloarthritis","volume":"36","author":"Bornstein G","year":"2018","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"e_1_2_6_16_1","first-page":"661","article-title":"The formation of autoantibodies and antibodies to TNF\u2010\u03b1 blocking agents in relation to clinical response in patients with ankylosing spondylitis","volume":"28","author":"Arends S","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200828"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/dmdi-2020-0139"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13636"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4258"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.135111"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.100826"},{"issue":"12","key":"e_1_2_6_24_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"issue":"12","key":"e_1_2_6_25_1","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index","volume":"21","author":"Calin A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2014.03.004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138594"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213184"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3386"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex474"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00312"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01951"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex434"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39691"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220097"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket260"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker124"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO;2-W"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204769"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01365"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203296"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141128"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1943-6"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1772-z"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802699278"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.23098"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00341-7"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.4172"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.42923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:20:40Z","timestamp":1759954840000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.42923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,14]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/art.42923"],"URL":"https:\/\/doi.org\/10.1002\/art.42923","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,14]]},"assertion":[{"value":"2023-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}