{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:07:51Z","timestamp":1790190471396,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031376","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Rhumatologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Recently, three distinct phenotypes of patients with Sj\u00f6gren disease (SjD) have been described based on cluster analysis: B cell active with low symptoms (BALS), high systemic activity (HSA), and low systemic activity with high symptoms (LSAHS). We aimed to assess whether these clusters were associated with distinct biomarkers and the prognostic value of interferon (IFN) signature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Assessment of Systemic Signs and Evolution in Sj\u00f6gren's Syndrome cohort is a 20\u2010year prospective cohort of patients with SjD. The following biomarkers were compared: IFN\u2010\u03b12, IFN\u2010\u03b3, CXCL10, CXCL13, BAFF, interleukin (IL)\u20107, fms\u2010like tyrosine kinase 3 ligand, CCL19, and tumor necrosis factor receptor 2 (TNF\u2010RII). IFN signature was assessed using transcriptomic analysis. We then compared systemic and symptomatic evolution, and the risk of new immunosuppressant prescription and of lymphoma, according to the IFN signature across the three clusters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 395 patients (94% female, median age 53 [interquartile range 43\u201363] years) were included. Higher levels of CXCL13, IL\u20107, and TNF\u2010RII were found in the BALS and HSA clusters compared with the LSAHS cluster. A high IFN signature was mainly found in the BALS cluster (57%, vs 48% and 38% in the HSA and LSAHS clusters, respectively). This IFN signature was mainly driven by type I IFN, with higher levels of IFN\u2010\u03b12. In the BALS cluster, a high IFN signature was associated with a higher risk of new immunosuppressant treatment (hazard ratio 9.38; 95% confidence interval 1.22\u201372.16). All lymphoma occurred in patients with high IFN signature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The three SjD clusters displayed distinct expressions of IFN signature and markers of T and B cell activation, confirming distinct pathophysiologic mechanisms. High IFN signature could predict systemic evolution in the BALS cluster.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43096","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T20:48:01Z","timestamp":1735159681000},"page":"876-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Distinct Pathophysiologic\u00a0Pathways Support Stratification of Sj\u00f6gren's Disease Based on Symptoms, Clinical, and Routine Biological Data"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-3824","authenticated-orcid":false,"given":"Yann","family":"Nguyen","sequence":"first","affiliation":[{"name":"H\u00f4pital Bic\u00eatre, Assistance Publique \u2013 H\u00f4pitaux de Paris, Universit\u00e9 Paris\u2010Saclay, Le Kremlin\u2010Bic\u00eatre, H\u00f4pital Beaujon, Assistance Publique \u2013 H\u00f4pitaux de Paris, Universit\u00e9 Paris Cit\u00e9, Clichy, Centre de Recherche en Epid\u00e9miologie et Statistiques, INSERM UMR 1153, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4924-093X","authenticated-orcid":false,"given":"Maxime","family":"Beydon","sequence":"additional","affiliation":[{"name":"H\u00f4pital Bic\u00eatre, Assistance Publique \u2013 H\u00f4pitaux de Paris, Universit\u00e9 Paris\u2010Saclay, Le Kremlin\u2010Bic\u00eatre, H\u00f4pital Beaujon, Assistance Publique \u2013 H\u00f4pitaux de Paris, Universit\u00e9 Paris Cit\u00e9  Clichy Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-946X","authenticated-orcid":false,"given":"Jacques\u2010Eric","family":"Gottenberg","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires de Strasbourg, Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-6385","authenticated-orcid":false,"given":"Jacques","family":"Morel","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Montpellier and PhyMedExp, Universit\u00e9 de Montpellier, INSERM, CNRS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleth","family":"Perdriger","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Rennes, Universit\u00e9 de Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Dernis","sequence":"additional","affiliation":[{"name":"General Hospital  Le Mans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-702X","authenticated-orcid":false,"given":"Divi","family":"Cornec","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Brest, INSERM 1227, LBAI, Universit\u00e9 de Bretagne Occidentale, Centre de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes Rares de l'Adulte  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-825X","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Devauchelle\u2010Pensec","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Brest, INSERM 1227, LBAI, Universit\u00e9 de Bretagne Occidentale, Centre de R\u00e9f\u00e9rence des Maladies Auto\u2010Immunes Rares de l'Adulte  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"S\u00e8ne","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lariboisi\u00e8re, Assistance Publique \u2013 H\u00f4pitaux de Paris  Paris 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Auto\u2010immune Diseases (IMVA), Institut pour la Sant\u00e9 et la Recherche M\u00e9dicale (INSERM) UMR 1184, Universit\u00e9 Paris\u2010Saclay  Le Kremlin\u2010Bic\u00eatre Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-0733","authenticated-orcid":false,"given":"Ga\u00ebtane","family":"Nocturne","sequence":"additional","affiliation":[{"name":"H\u00f4pital Bic\u00eatre, Assistance Publique \u2013 H\u00f4pitaux de Paris, Universit\u00e9 Paris\u2010Saclay, Center for Immunology of Viral Infections and Auto\u2010immune Diseases (IMVA), Institut pour la Sant\u00e9 et la Recherche M\u00e9dicale (INSERM) UMR 1184, Universit\u00e9 Paris\u2010Saclay  Le Kremlin\u2010Bic\u00eatre Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","first-page":"97","article-title":"Primary Sj\u00f6gren's 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