{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:17:58Z","timestamp":1788319078394,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K24AR081368"],"award-info":[{"award-number":["K24AR081368"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR072580"],"award-info":[{"award-number":["P30AR072580"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR077060"],"award-info":[{"award-number":["R01AR077060"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["Innovative research award"],"award-info":[{"award-number":["Innovative research award"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Our study objectives were (1) to determine associations among ultrasound (US) features of knee osteoarthritis (KOA), radiographic KOA (rKOA), and patient\u2010reported symptoms and (2) to determine diagnostic accuracy of US definitions for rKOA, in a community\u2010based cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants enrolled in the Johnston County Health Study (JoCoHS; 2019\u20132024, n = 902) provided demographics, comorbidities, clinical features, and symptoms, along with imaging with standardized acquisition and scoring protocols. Logistic regression models provided odds ratios adjusted for age, sex, race, ethnicity, body mass index (BMI), education level, comorbidities, and knee injury for associations among US features and KOA outcomes. Diagnostic accuracy was assessed using standard metrics with rKOA as the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete imaging data were available for 861 participants (1,711 knees): 34% men, 25% Black, 10% Hispanic, mean age 55 years, and mean BMI 33. Half of knees were symptomatic, one\u2010third had rKOA, and one in five had symptomatic rKOA. US\u2010identified osteophytes, effusion, meniscal extrusion, cartilage damage, calcium crystals, and popliteal cysts were associated with KOA outcomes. A US definition including both mild osteophytes and mild cartilage damage gave an area under the receiver operating characteristic curve of 0.76 for diagnosing rKOA (validated in an external cohort).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified common US features in participants with and without KOA, along with significant associations between US features and rKOA, symptomatic rKOA, and symptoms. US\u2010based diagnosis of rKOA shows promise for general use. US is a valuable and accessible modality for assessment of knee OA features in clinical and research settings, including those with limited resources.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art43139-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/art.43139","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T20:16:50Z","timestamp":1740514610000},"page":"996-1005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations and Diagnostic Accuracy of Ultrasound Features in Knee Osteoarthritis: Cross\u2010Sectional Results From a Large Community\u2010Based 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