{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:32:34Z","timestamp":1787934754122,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by using high\u2010resolution peripheral quantitative computed tomography (HR\u2010pQCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a phase 4, double\u2010blind, randomized, placebo\u2010controlled trial. Patients with active PsA and \u22651 erosion in metacarpophalangeal joints (MCPJs) 2 to 4 were randomly assigned in a 1:1 ratio to subcutaneous secukinumab or placebo. HR\u2010pQCT of MCPJs 2 to 4 were performed at baseline, week 24, and week 48. The primary outcome was the changes in the volume of erosions on MCPJs 2 to 4 measured by HR\u2010pQCT at 24 and 48 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients (mean \u00b1 SD age 51.9 \u00b1 13.4 years, 20 [50%] male, mean \u00b1 SD disease duration 4.7 \u00b1 6.7 years) were recruited. Thirty\u2010four patients who completed study treatment were included in the per\u2010protocol analysis. At baseline, week 24, and week 48, the secukinumab group showed a significant reduction in erosion volume, whereas no changes were observed in the placebo group (median change in the secukinumab group \u22120.1 [interquartile range \u22120.5 to 0.0] vs 0.0 [interquartile range \u22120.2 to 0.4] in the placebo group, <jats:italic>P<\/jats:italic> = 0.004). A similar trend was observed for enthesiophyte volume changes in the secukinumab group, whereas no differences were noted in the placebo group (median change in the secukinumab group \u22120.1 [interquartile range \u22120.8 to 0.0] vs 0.0 [interquartile range \u22120.4 to 1.3] in the placebo group, <jats:italic>P<\/jats:italic> = 0.067). Generalized estimating equations results showed that the odds ratio (OR) for enthesiophyte progression in the secukinumab group was 0.264 (95% confidence interval [CI] 0.080\u20130.878, <jats:italic>P<\/jats:italic> = 0.030), whereas the OR for partial erosion healing in the secukinumab group was 2.882 (95% CI 1.130\u20137.349, <jats:italic>P<\/jats:italic> = 0.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Secukinumab demonstrates a potential benefit in facilitating partial erosion repair and preventing enthesiophyte progression in PsA.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art43154-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/art.43154","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T03:44:37Z","timestamp":1741923877000},"page":"1015-1025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Secukinumab on Enthesiophyte and Erosion Progression in Psoriatic Arthritis: A One\u2010Year Double\u2010Blind, Randomized, Placebo\u2010Controlled Trial Using High\u2010Resolution Peripheral Quantitative Computed Tomography"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-2172","authenticated-orcid":false,"given":"Yingzhao","family":"Jin","sequence":"first","affiliation":[{"name":"The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac T.","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho","family":"So","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy T.","family":"Lai","sequence":"additional","affiliation":[{"name":"Tseung Kwan O Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley K.","family":"Ying","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitty Y.","family":"Kwok","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Griffith","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong  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