{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:12:48Z","timestamp":1791364368172,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110748"],"award-info":[{"award-number":["2023A1515110748"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011794"],"award-info":[{"award-number":["2024A1515011794"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Sarcopenia and knee osteoarthritis (KOA) are common conditions in older adults, but their relationship is controversial. We aimed to examine the potential role of sarcopenia in KOA progression and subsequent knee replacement (KR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from the Osteoarthritis Initiative, baseline sarcopenia was first screened according to the EWGSOP2 algorithm using the SARC\u2010F (Strength, Assistance with walking, Rise from a chair, Climb stairs, and Falls) questionnaire (screened sarcopenia [Scre\u2010S]), then further assessed combined with the five times chair\u2010stand\u2010test (probable sarcopenia [Prob\u2010S]). Radiographic KOA progression was evaluated by changes in Kellgren\u2010Lawrence Grade and Osteoarthritis Research Society International atlas scores from baseline to the 24\u2010 and 48\u2010month follow\u2010ups. Symptomatic progression was evaluated similarly using the Western Ontario McMaster Osteoarthritis Index. The associations of sarcopenia with radiographic or symptomatic progression and subsequent KR were analyzed before and after adjusting for potential confounders and propensity score (PS) matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4,316 participants were included; 27.2% were Scre\u2010S and 16.8% were Prob\u2010S. Baseline Scre\u2010S and Prob\u2010S were positively associated with both radiographic and symptomatic progression in KOA over 24 and 48\u2009months. Both Scre\u2010S and Prob\u2010S were associated with a higher risk of subsequent KR (Scre\u2010S: hazard ratio [HR] 3.84, 95% confidence interval [CI] 3.18 to 4.62; Prob\u2010S: HR 2.29, 95% CI 1.87 to 2.81). These results remained significant in the PS\u2010matched cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Scre\u2010S and Prob\u2010S were significantly and longitudinally associated with both radiographic and symptomatic progression in KOA and subsequent KR. Our findings indicated a potential causal role of sarcopenia in KOA progression and highlighted its potentially therapeutic effect in KOA management.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art43213-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/art.43213","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:15:04Z","timestamp":1746497704000},"page":"1362-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement"],"prefix":"10.1002","volume":"77","author":[{"given":"Tianxing","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Orthopaedic Surgery, Department of Orthopedics, Nanfang Hospital, Southern Medical University and Clinical Research Centre and The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojian","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, Department of Orthopedics Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihua","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Dang","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Xie","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Nanfang Hospital Southern Medical University  Guangzhou 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