{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:56:36Z","timestamp":1792626996046,"version":"4.5.0"},"reference-count":111,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self\u2010resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal\u2013induced inflammation is reviewed in detail. Treatment strategies for gout are outlined in the context of the mechanisms of NLRP3 inflammasome\u2013mediated acute inflammation.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art43215-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1002\/art.43215","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T10:05:37Z","timestamp":1746439537000},"page":"1317-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Gout and\n                    <scp>NLRP3<\/scp>\n                    Inflammasome Biology"],"prefix":"10.1002","volume":"77","author":[{"given":"Raewyn","family":"Poulsen","sequence":"first","affiliation":[{"name":"Department of Pharmacology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-4476","authenticated-orcid":false,"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_2_1_10_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-54-3-452"},{"key":"e_1_2_1_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206397"},{"key":"e_1_2_1_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)90501-9"},{"key":"e_1_2_1_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1941.02820060001001"},{"key":"e_1_2_1_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(73)80013-9"},{"key":"e_1_2_1_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"e_1_2_1_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng756"},{"key":"e_1_2_1_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21238"},{"key":"e_1_2_1_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52543-8"},{"key":"e_1_2_1_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13292"},{"key":"e_1_2_1_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"e_1_2_1_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.02.008"},{"key":"e_1_2_1_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.054"},{"key":"e_1_2_1_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.244"},{"key":"e_1_2_1_10_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172222"},{"key":"e_1_2_1_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/356768a0"},{"key":"e_1_2_1_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.013"},{"key":"e_1_2_1_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00751.x"},{"key":"e_1_2_1_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_1_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00670-3"},{"key":"e_1_2_1_10_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363"},{"key":"e_1_2_1_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0"},{"key":"e_1_2_1_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17669-5"},{"key":"e_1_2_1_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-018-0354-y"},{"key":"e_1_2_1_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.03.004"},{"key":"e_1_2_1_10_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250684"},{"key":"e_1_2_1_10_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.407130"},{"key":"e_1_2_1_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217342"},{"key":"e_1_2_1_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213005"},{"key":"e_1_2_1_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1714-9"},{"key":"e_1_2_1_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224731"},{"key":"e_1_2_1_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39107"},{"key":"e_1_2_1_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12436"},{"key":"e_1_2_1_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010022\u201001693\u20108"},{"key":"e_1_2_1_10_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94584"},{"key":"e_1_2_1_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27667"},{"key":"e_1_2_1_10_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620910114"},{"key":"e_1_2_1_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1631"},{"key":"e_1_2_1_10_40_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.124388"},{"key":"e_1_2_1_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"},{"key":"e_1_2_1_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1413-8"},{"key":"e_1_2_1_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16143-6"},{"key":"e_1_2_1_10_44_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190111"},{"key":"e_1_2_1_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.013"},{"key":"e_1_2_1_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.171"},{"key":"e_1_2_1_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/44605"},{"key":"e_1_2_1_10_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206564"},{"key":"e_1_2_1_10_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208767"},{"key":"e_1_2_1_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.015"},{"key":"e_1_2_1_10_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203803"},{"key":"e_1_2_1_10_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.10.2944"},{"key":"e_1_2_1_10_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2210"},{"key":"e_1_2_1_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-00978-0"},{"key":"e_1_2_1_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu436"},{"key":"e_1_2_1_10_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1171-8"},{"key":"e_1_2_1_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.95"},{"key":"e_1_2_1_10_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206074"},{"key":"e_1_2_1_10_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1699-4"},{"key":"e_1_2_1_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.03.008"},{"key":"e_1_2_1_10_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196371"},{"key":"e_1_2_1_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2015.12.002"},{"key":"e_1_2_1_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33355"},{"key":"e_1_2_1_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3547"},{"key":"e_1_2_1_10_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6261"},{"key":"e_1_2_1_10_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206966"},{"key":"e_1_2_1_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(02)00010-1"},{"key":"e_1_2_1_10_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00376"},{"key":"e_1_2_1_10_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-016-1008-0"},{"key":"e_1_2_1_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01661-3"},{"key":"e_1_2_1_10_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_1_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1944"},{"key":"e_1_2_1_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10709"},{"key":"e_1_2_1_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03988"},{"key":"e_1_2_1_10_75_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113970"},{"key":"e_1_2_1_10_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37822"},{"key":"e_1_2_1_10_77_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10561"},{"key":"e_1_2_1_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429"},{"key":"e_1_2_1_10_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175336"},{"key":"e_1_2_1_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/89759"},{"key":"e_1_2_1_10_81_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.8.1197"},{"key":"e_1_2_1_10_82_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081880"},{"key":"e_1_2_1_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2016.03.004"},{"key":"e_1_2_1_10_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780291209"},{"key":"e_1_2_1_10_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340203"},{"key":"e_1_2_1_10_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360912"},{"key":"e_1_2_1_10_87_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222764"},{"key":"e_1_2_1_10_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb10020018"},{"key":"e_1_2_1_10_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39254"},{"key":"e_1_2_1_10_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27356"},{"key":"e_1_2_1_10_91_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2070"},{"key":"e_1_2_1_10_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216154"},{"issue":"2","key":"e_1_2_1_10_93_1","first-page":"S25","article-title":"Polymorphonuclear leukocyte motility in vitro: IV. Colchicine inhibition of chemotactic activity formation after phagocytosis of urate crystals","volume":"58","author":"Phelps P.","year":"2008","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_10_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2550"},{"key":"e_1_2_1_10_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.20"},{"key":"e_1_2_1_10_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018993"},{"key":"e_1_2_1_10_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00526-2"},{"key":"e_1_2_1_10_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.2.752"},{"key":"e_1_2_1_10_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053936"},{"key":"e_1_2_1_10_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07282-7"},{"key":"e_1_2_1_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio231232a0"},{"key":"e_1_2_1_10_102_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.6.3406"},{"key":"e_1_2_1_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/34184"},{"key":"e_1_2_1_10_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key402"},{"key":"e_1_2_1_10_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41699"},{"key":"e_1_2_1_10_106_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200908"},{"key":"e_1_2_1_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(20)30065-5"},{"key":"e_1_2_1_10_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24180"},{"key":"e_1_2_1_10_109_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118147"},{"key":"e_1_2_1_10_110_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1012510"},{"issue":"1","key":"e_1_2_1_10_111_1","first-page":"i12","article-title":"The role of IL\u20101 in gout: from bench to bedside","volume":"57","author":"So A","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_1_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.155"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.43215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T01:01:40Z","timestamp":1759194100000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.43215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":111,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/art.43215"],"URL":"https:\/\/doi.org\/10.1002\/art.43215","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"assertion":[{"value":"2024-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}