{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:11:33Z","timestamp":1788786693201,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the impact of differences in the timing of initial biologic disease\u2010modifying antirheumatic drug (bDMARD) therapy using the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Start Time Optimization of biologics in Polyarticular Juvenile Idiopathic Arthritis (JIA) (STOP\u2010JIA) \u2013 consensus treatment plans study on outcomes through three years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Start Time Optimization of biologics in Polyarticular\u2010JIA participants with CARRA Registry follow\u2010up through three years were eligible. Outcomes included American College of Rheumatology clinically inactive disease (CID) off glucocorticoids, clinical Juvenile Arthritis Disease Activity Score based on 10 joints inactive disease (cJADAS\u201010\u2010ID) (cJADAS\u201010\u2010ID: cJADAS\u201010 \u2264 2.5), clinical remission on medication (CRM), and proportion of time in CID and\/or cJADAS\u201010\u2010ID. Latent class trajectory modeling (LCTM) was applied to identify participant subgroups sharing similar disease courses over this period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 297 participants were included (n = 190 step\u2010up [SU], 76 early combination [EC], and 31 biologic first). At the three\u2010year visit, CID was achieved by 35%, 42%, and 44%, respectively (<jats:italic>P<\/jats:italic> = 0.35 for SU versus EC). EC was superior to SU in achieving CRM (59.9% vs 40.6%; <jats:italic>P<\/jats:italic> = 0.012), time spent in CID (38% versus 30%; <jats:italic>P<\/jats:italic> = 0.04), and cJADAS\u201010\u2010ID (51% versus 41%; <jats:italic>P<\/jats:italic> = 0.02). Slow, moderate, and rapid improvement trajectories were identified by LCTM; bDMARD initiation within the first (odds ratio [OR] 5.33) or second (OR 2.67) month from baseline was associated with the rapid improvement trajectory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EC was superior to SU across three years for outcomes reflecting time spent in lower disease activity. Starting bDMARD within two months predicted rapid improvement and maintenance of inactive disease. These results support the hypothesis that early bDMARD initiation reduces overall disease burden in pJIA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.43216","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T01:49:23Z","timestamp":1746755363000},"page":"1433-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Three\u2010Year Outcomes and Latent Class Trajectory Analysis of the Childhood Arthritis and Rheumatology Research Alliance Polyarticular <scp>JIA<\/scp> Consensus Treatment Plans Study"],"prefix":"10.1002","volume":"77","author":[{"given":"Sarah","family":"Ringold","sequence":"first","affiliation":[{"name":"University of Washington  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1241-1013","authenticated-orcid":false,"given":"Mei\u2010Sing","family":"Ong","sequence":"additional","affiliation":[{"name":"Computational Health Informatics Program Boston Children's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc D.","family":"Natter","sequence":"additional","affiliation":[{"name":"Computational Health Informatics Program Boston Children's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1913-6472","authenticated-orcid":false,"given":"Laura E.","family":"Schanberg","sequence":"additional","affiliation":[{"name":"Duke University Medical Center  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Del Gaizo","sequence":"additional","affiliation":[{"name":"CARRA, Inc."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-9665","authenticated-orcid":false,"given":"Brian M.","family":"Feldman","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Murphy","sequence":"additional","affiliation":[{"name":"CARRA, Inc."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-3390","authenticated-orcid":false,"given":"Yukiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Joseph M Sanzari Children's Hospital, Hackensack Meridian School of Medicine  Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CARRA Registry STOP\u2010JIA Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21389"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep144"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20497"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11485"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41888"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41892"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22259"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41888"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34343"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41879"},{"key":"e_1_2_8_13_1","unstructured":"CefaluM.RidgewayG McCaffreyD et al.twang: Toolkit for Weighting and Analysis of Nonequivalent Groups. 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