{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:08:30Z","timestamp":1793207310002,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The SEMAPHORE trial evaluated the efficacy and safety of tocilizumab (TCZ) treatment in patients with glucocorticoid (GC)\u2010dependent polymyalgia rheumatica (PMR). TCZ reduced GC dose and disease activity at week 24. This study aimed to assess relapse rates after stopping TCZ treatment in patients achieving remission at week 24.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the randomized study, 101 patients received intravenous TCZ (8 mg\/kg) or placebo for 24 weeks. Of the 49 patients treated with TCZ, 33 achieved the primary outcome (PMR activity score &lt;10 and GC dose reduction of \u22645 mg\/day or \u226510 mg). All 33 patients except one stopped TCZ treatment at week 24 and completed a visit at week 32, with optional follow\u2010up visits every eight weeks until week 48. Relapse was defined as the failure of the primary composite outcome during follow\u2010up or the need for one or more TCZ infusion. Results were analyzed using Kaplan\u2010Meier curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 33 patients who received TCZ in remission at week 24, seven stopped follow\u2010ups before week 48, and two of the remaining 26 patients (7.7%) sustained remission in the following six months. 24 (92.3%) of the total patients experienced a relapse. The median time to relapse was 15 weeks (interquartile range, 8\u201325 weeks).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients with GC\u2010dependent PMR in remission after a six\u2010month TCZ treatment, only a minority of the patients remained relapse\u2010free after TCZ discontinuation. This study suggests that a six\u2010month treatment course is not long enough to withdraw the TCZ. Further studies are needed to determine the optimal TCZ treatment duration and strategies for cessation to prevent relapses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43221","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T23:50:38Z","timestamp":1746661838000},"page":"1416-1420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Maintenance of Remission After Tocilizumab Withdrawal in Patients With Glucocorticoid\u2010Dependent Polymyalgia Rheumatica"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-7603","authenticated-orcid":false,"given":"Baptiste","family":"Chevet","sequence":"first","affiliation":[{"name":"Rheumatology Department, Brest University Hospital and INSERM 1227 Brest University  Brest 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