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To help elucidate the diversity of SSc presentation in its early stages, we describe the initial clinical manifestations and antinuclear antibody (ANA) profiles of patients in two early SSc cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patient data in the Genetics vs Environment in Scleroderma Outcomes Study (GENISOS) and Collaborative National Quality and Efficacy Registry (CONQUER) cohorts were reviewed. Both studies enrolled patients within five years of the first non\u2010RP symptom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In GENISOS and CONQUER, respectively, 194 (44.2%) of 439 and 292 (31.1%) of 938 patients had a non\u2010RP initial symptom, most commonly puffy fingers\/hands. Black patients had a non\u2010RP symptom before RP more commonly than patients in other race and ethnicity categories. Non\u2010RP first patients were more likely than RP first patients to have diffuse cutaneous involvement and joint contractures at enrollment and had a higher prevalence of RNA polymerase III antibody positivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In two large US cohorts, &gt;30% of patients began to manifest SSc with puffy fingers\/hands or other symptoms, without the \u201cwarning sign\u201d of RP as their initial symptom. These patients presented with more severe skin and musculoskeletal disease on average, highlighting the importance of early recognition. The most common autoantibody associated with this presentation was RNA polymerase III. These results should be considered in efforts to recognize SSc in its earliest stages. Puffy fingers\/hands, even in the absence of RP, should prompt consideration of early SSc and testing for ANA and SSc\u2010associated autoantibodies, including RNA polymerase III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43237","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T06:21:09Z","timestamp":1747635669000},"page":"1585-1595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hand Swelling and Other Non\u2013Raynaud Phenomenon Symptoms as the Initial Presentation of Systemic Sclerosis: Prevalence and Clinical Associations in Two\n                    <scp>US<\/scp>\n                    Cohorts"],"prefix":"10.1002","volume":"77","author":[{"given":"Iqtidar","family":"Hanif","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center at 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