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This multistep process involves recognizing, binding, internalizing, and degrading ACs. Efferocytosis clears ACs, preventing their secondary necrosis, generating anti\u2010inflammatory mediators, and promoting the resolution of inflammation. Appropriate efferocytosis is essential for preserving immune tolerance and preventing exposure to self\u2010antigens, whereas defective efferocytosis is linked to the onset of various rheumatic diseases. Here, we review the process of efferocytosis and its implications in common rheumatic diseases. This review focuses on the role of abnormal efferocytosis in the development and progression of systemic lupus erythematosus. We also summarize recent advances in understanding efferocytosis in other rheumatic diseases, including rheumatoid arthritis (RA), Sj\u00f6gren disease, antineutrophil cytoplasmic antibody\u2013associated vasculitis, systemic sclerosis, antiphospholipid syndrome, gout, and osteoarthritis. Notably, a clinical trial investigating AC infusion for refractory RA has been proposed, highlighting the therapeutic potential of targeting efferocytosis. In addition, emerging strategies\u2014such as liver X receptor\/peroxisome proliferator\u2010activated receptor agonists; DNase\u2010containing nanoparticles; Tyro3, Axl, and Mer receptor agonists; and anti\u2010CD47 antibodies\u2014show promise, although most remain at the preclinical stage. Despite the challenges posed by the immune system's complexity and the pleiotropic functions of efferocytosis\u2010related molecules, growing evidence supports efferocytosis as a potential therapeutic target in rheumatic diseases.<\/jats:p>","DOI":"10.1002\/art.43268","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T03:13:42Z","timestamp":1748834022000},"page":"1635-1650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efferocytosis and Its Role in Rheumatic Diseases"],"prefix":"10.1002","volume":"77","author":[{"given":"Xiaoyu","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Second Xiangya Hospital of Central South University and Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province  Changsha 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