{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:15:27Z","timestamp":1791195327229,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to evaluate the influence of contrast\u2010enhanced dual\u2010energy computed tomography (CE\u2010DECT) in detecting and differentiating rheumatic joint diseases of the hand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, patients with suspected arthritis of the hand were investigated consecutively alongside the standard clinical procedure. CE\u2010DECT with sequential rotations was performed in all patients before and 3\u2010minutes after weight\u2010adapted contrast agent application. Reconstructions included two\u2010material decomposition for tophus imaging, virtual noncalcium for bone marrow edema, and CT subtraction for soft\u2010tissue inflammation. All postprocessed images and original CT reconstructions were rated by two radiologists in consensus to generate an imaging diagnosis. Imaging findings in CE\u2010DECT were juxtaposed with the initial and final evaluations by referring rheumatologists. This evaluation focused on surrogate performance criteria, emphasizing the added diagnostic value of CE\u2010DECT in detecting specific imaging biomarkers associated with various arthritic pathologies. A subsequent survey assessed CE\u2010DECT's diagnostic utility and impact on patient management, rated on a 1 to 10 scale. Descriptive statistics were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 136 patients were included in the analysis. In 119 patients (87.5%), the CE\u2010DECT findings agreed with the final diagnosis. In 67 patients (49.2%), the diagnosis was changed following CE\u2010DECT. Rheumatologists rated CE\u2010DECT's diagnostic utility at a mean \u00b1 SD of 8.5 \u00b1 2.1 and its contribution to patient management at 8.4 \u00b1 1.8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CE\u2010DECT showed high value for diagnosis and management of patients with suspected inflammatory arthritis. Its diverse diagnostic capabilities suggest that it can develop an important addition to current clinical workup pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43270","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:18:19Z","timestamp":1748935099000},"page":"1655-1662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Impact of Multiparametric Contrast\u2010Enhanced Dual\u2010Energy Computed Tomography in Arthritis Imaging: A Prospective Single\u2010Center Study"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3871-3746","authenticated-orcid":false,"given":"Sevtap Tugce","family":"Ulas","sequence":"first","affiliation":[{"name":"Department of Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Mitte, Humboldt \u2013 Universit\u00e4t zu Berlin, Freie Universit\u00e4t Berlin  Berlin 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Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Mitte, Humboldt \u2013 Universit\u00e4t zu Berlin, Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Ziegeler","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Mitte, Humboldt \u2013 Universit\u00e4t zu Berlin, Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-033X","authenticated-orcid":false,"given":"Fabian","family":"Proft","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Infectious Diseases, and Rheumatology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin 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