{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:06:25Z","timestamp":1791648385899,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012781","name":"Merck Sharp and Dohme K.K.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of tight\u2010control, rapid escalation to tumor necrosis factor inhibition in early axial spondyloarthritis (axSpA) in relation to gut inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>GO\u2010GUT (NCT03270501) was a prospective, open\u2010label, 52\u2010week trial in treatment\u2010na\u00efve patients with axSpA with less than one year of symptom duration and high disease activity. At baseline, patients underwent ileocolonoscopy with histopathological evaluation of the gut mucosa. Next, all patients received two different nonsteroidal anti\u2010inflammatory drugs in optimal dose for a period of four weeks. If inactive disease, defined as Ankylosing Spondylitis Disease Activity Score (ASDAS) with CRP &lt;1.3, or clinically important improvement (\u0394ASDAS\u2010CRP \u2265 1.1) resulting in low disease activity (ASDAS\u2010CRP &lt;2.1) was not achieved, monotherapy with 50 mg golimumab every four weeks was initiated. Patients were observed until they achieved sustained clinical remission (ASDAS\u2010CRP &lt;1.3 at two consecutive visits with 12 weeks interval) or end of trial. Upon achievement of sustained clinical remission, all medication was discontinued, and the possibility of drug\u2010free remission was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010eight patients were included in the trial. Microscopic gut inflammation was present in 28.6% of patients, which was predominantly acute inflammation. An escalation of therapy to golimumab was required for 72.7% of patients. The primary study endpoint of sustained clinical remission was reached by 61.8% of patients, irrespective of gut inflammation. Treatment discontinuation resulted in disease relapse within one year in 78.1% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Applying a treat\u2010to\u2010target approach in treatment\u2010na\u00efve early axSpA allows to induce high rates of sustained clinical remission, regardless of the presence of microscopic gut inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43283","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T02:29:42Z","timestamp":1750127382000},"page":"119-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Golimumab in Early Axial Spondyloarthritis in Relation to Gut Inflammation: An Early Remission Induction 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Medicine and Paediatrics and European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-9044","authenticated-orcid":false,"given":"Liselotte","family":"Deroo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Varkas","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Molecular Immunology and Inflammation Unit, VIB\u2010UGent Center for Inflammation Research Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manouk","family":"de Hooge","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Ghent University Hospital  Ghent 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