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We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell phenotype and clonality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using single\u2010cell RNA sequencing (n = 6 skin samples with n = 5 paired synovial tissue samples and\/or n = 5 paired synovial fluid samples) and spatial transcriptomics (n = 1 paired skin and synovial biopsy sample, n = 4 unpaired biopsy samples), we compared the transcriptional signature, T cell receptor repertoire, and cell neighborhoods of T cells from skin and synovial tissue and\/or fluid samples from patients with PsA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified an enrichment of type 17 CD8\n                      <jats:sup>+<\/jats:sup>\n                      tissue\u2010resident memory T (Trm) cells in both the skin and joint, with a stronger interleukin\u201017 signature in the skin than the joint. CD8\n                      <jats:sup>+<\/jats:sup>\n                      Trm cells resided in distinct cell neighborhoods in the skin and joint but were located adjacent to antigen\u2010presenting cells in both sites. Several T cell clones were shared between the skin and joint. Across the six patients, 155 CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell clones were shared between the two sites, comprising 1,071 CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells and taking up a median of 13% of the skin and 8% of the joint CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell receptor repertoire. CD8\n                      <jats:sup>+<\/jats:sup>\n                      skin\u2013joint shared clones tended to have a similar phenotype at both sites, characterized by increased expression of genes associated with a cytotoxic, tissue\u2010resident phenotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings support the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell clonality and that specific T cells migrate between these compartments to propagate inflammation across both sites.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43286","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:24:06Z","timestamp":1750209846000},"page":"152-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8\n                    <sup>+<\/sup>\n                    T Cell Clones"],"prefix":"10.1002","volume":"78","author":[{"given":"Lucy E.","family":"Durham","sequence":"first","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology School of Immunology and Microbial Sciences, King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Humby","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Guy's and St Thomas\u2019 NHS Foundation Trust  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Guy's and St Thomas\u2019 NHS Foundation Trust  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Laddach","sequence":"additional","affiliation":[{"name":"Spatial Biology Facility, Guy's Cancer Centre, Faculty of Life Sciences and Medicine and Faculty of Dentistry, Oral and Craniofacial Sciences King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H.","family":"Gray","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology School of Immunology and Microbial Sciences, King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology School of Immunology and Microbial Sciences, King's College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J. 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