{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:35:02Z","timestamp":1792143302670,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis & Rheumatology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"\n Objective<\/jats:title>\n \n Vacuoles E1 enzyme X\u2010linked autoinflammatory somatic syndrome (VEXAS) is a recently identified rare genetic disorder associated with somatic mutations in the\n UBA1<\/jats:italic>\n gene. VEXAS presents with a combination of inflammatory and hematologic manifestations, leading to increased morbidity and mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Given the variability in disease presentation and the limited number of studies to date, no clinical documents currently exist to provide guidance to health care providers about the management of VEXAS. To address this gap, we formed an international multidisciplinary panel of VEXAS experts.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Through formalized meetings and a voting process, the group developed consensus clinical guidance considerations for the management of VEXAS. These considerations offer practical advice on several key topics: (1) clinical features of VEXAS, (2)\n UBA1<\/jats:italic>\n screening methods, (3) the diagnosis of myelodysplastic syndromes (MDSs) in patients with VEXAS, and (4) prognosis and management. The aim is to provide expert guidance on which patients to test, how to test for VEXAS, how to approach MDS in the context of VEXAS, and considerations for management.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This work marks the first formal international consensus guidance for VEXAS and is intended to be used as a resource for clinicians seeking to understand the disease and its management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.43287","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:00:16Z","timestamp":1754913616000},"page":"509-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["American College of Rheumatology Guidance Statement for Diagnosis and Management of\n VEXAS<\/scp>\n Developed by the International\n VEXAS<\/scp>\n Working Group Expert Panel"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2849-3049","authenticated-orcid":false,"given":"Arsene","family":"Mekinian","sequence":"first","affiliation":[{"name":"Service de m\u00e9decine interne, H\u00f4pital Saint Antoine, Assistance Publique Hopitaux de Paris, Sorbonne Universit\u00e9, Imagine Institute, CEREMAIAA reference center Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Georgin\u2010Lavialle","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hopital Tenon, Assistance Publique Hopitaux de Paris, Sorbonne University, CEREMAIAA reference center Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela A.","family":"Ferrada","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Medicine Baltimore, University of Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinisa","family":"Savic","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds Leeds United Kingdom"},{"name":"National Institute for Health and Care Research (NIHR)\u2010Leeds Biomedical Research Centre Leeds United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-6755","authenticated-orcid":false,"given":"Matthew J.","family":"Koster","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Kosmider","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, Institut Cochin, CNRS UMR8104, INSERM U1016 Paris France"},{"name":"Hematology Laboratory Cochin Hopital, Assistance Publique\u2010H\u00f4pitaux de Paris, Universit\u00e9 de Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Comont","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine interne, Centre Hospitalier Universitaire de Toulouse, Universit\u00e9 Toulouse III\u2010Paul Sabatier Facult\u00e9 de sant\u00e9, Pole IUC de Toulouse Oncopole CHU Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mael","family":"Heiblig","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique, Hospices Civils de Lyon, H\u00f4pital Lyon Sud Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan I.","family":"Arostegui","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital Cl\u00ednic Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"},{"name":"School of Medicine, Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annmarie","family":"Bosco","sequence":"additional","affiliation":[{"name":"Hematology Department Prince of Wales Hospital Sydney New South Wales Australia"},{"name":"Hematology Department NSW Health Pathology Randwick Sydney New South Wales Australia"},{"name":"Prince of Wales Clinical School, University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-9074","authenticated-orcid":false,"given":"Rim","family":"Bourguiba","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pital des forces de s\u00e9curit\u00e9 de l'int\u00e9rieur Tunis Tunisia"},{"name":"Universit\u00e9 Tunis el Manar Facult\u00e9 de m\u00e9decine de Tunis Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine R.","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cargo","sequence":"additional","affiliation":[{"name":"Hematological Malignancy Diagnostic Service Leeds Cancer Centre, St James's University Hospital Leeds United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"ASST Spedali Civili of Brescia University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Chasset","sequence":"additional","affiliation":[{"name":"Dermatology and Allergology Department Assistance Publique Hopitaux de Paris, Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Hematology Centro Hospitalar Vila Nova de Gaia Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-3794","authenticated-orcid":false,"given":"Corrado","family":"Campochiaro","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Rheumatology Allergy and Rare Diseases (UnIRAR), IRCCS Ospedale San Raffaele & Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-1538","authenticated-orcid":false,"given":"Francesca","family":"Crisafulli","sequence":"additional","affiliation":[{"name":"ASST Spedali Civili of Brescia University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Ducharme\u2010Benard","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine interne H\u00f4pital du Sacr\u00e9\u2010C\u0153ur de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Faria","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cl\u00ednica, Unidade Local de Sa\u00fade Santo Ant\u00f3nio (ULSSA) Porto Portugal"},{"name":"Autoimmunity and Neurosciences Group, UMIB \u2010 Unit for Multidisciplinary Research in Biomedicine ICBAS \u2010 School of Medicine and Biomedical Sciences, University of Porto Porto Portugal"},{"name":"ITR \u2010 Laboratory for Integrative and Translational Research in Population Health Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia and Department of Clinical and Experimental Sciences University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micol","family":"Frassi","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia and Department of Clinical and Experimental Sciences University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma M.","family":"Groarke","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung Blood Institute, National Institute of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-5544","authenticated-orcid":false,"given":"Carmelo","family":"Gurnari","sequence":"additional","affiliation":[{"name":"Department of Translational Hematology and Oncology Research Taussig Cancer Institute, Cleveland Clinic Cleveland OH USA"},{"name":"Department of Biomedicine and Prevention University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yervand","family":"Hakobyan","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology Yeolyan Hematology Center, Yerevan, Armenia; Department of Hematology and Transfusion Medicine, National Institute of Health Yerevan Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-3650","authenticated-orcid":false,"given":"Yvan","family":"Jamilloux","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine interne H\u00f4pital de la Croix Rousse, Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Jurcut","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dr. Carol Davila Central Military Emergency University Hospital Bucharest 010825 Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-661X","authenticated-orcid":false,"given":"Yohei","family":"Kirino","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Kulasekararaj","sequence":"additional","affiliation":[{"name":"Department of Hematology Kings College Hospital and Kings College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Kunimoto","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Madigan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u0159man F.","family":"Mann","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-1410","authenticated-orcid":false,"given":"Chiara","family":"Marvisi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Azienda Unit\u00e0 Sanitaria Locale\u2010IRCCS di Reggio Emilia Reggio Emilia Italy"},{"name":"University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-8768","authenticated-orcid":false,"given":"Marcin","family":"Milchert","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases Rheumatology Diabetology Geriatrics and Clinical Immunology with the Sub\u2010Department of Gastroenterology Pomeranian Medical University in Szczecin Szczecin Poland.D43:N68"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Morais","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Sockel","sequence":"additional","affiliation":[{"name":"Medical Clinic and Policlinic I, University Hospital Dresden TU Dresden Dresden Germany"},{"name":"German Cancer Consortium (DKTK), CHOICE Consortium Partner Sites, MunichDresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Muratore","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia Modena Italy"},{"name":"Azienda Unit\u00e0 Sanitaria Locale\u2010IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal M.","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa","family":"Regadas","sequence":"additional","affiliation":[{"name":"Centro Hospitalar e Universit\u00e1rio do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Robin","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie\u2010greffe, H\u00f4pital Saint\u2010Louis, Assistance Publique Hopitaux de Paris, Universit\u00e9 de Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1641-6890","authenticated-orcid":false,"given":"Abraham","family":"Rutgers","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology University Medical Center Groningen, University of Groningen 9713 GZ Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-3148","authenticated-orcid":false,"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia Modena Italy"},{"name":"Azienda Unit\u00e0 Sanitaria Locale\u2010IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Sammel","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School, University of New South Wales Sydney New South Wales Australia"},{"name":"Rheumatology Department Prince of Wales Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Seebach","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Allergy, Department of Medical Specialties University Hospital and Faculty of Medicine Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sujobert","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology H\u00f4pital Lyon Sud, Hospices Civils de Lyon Pierre B\u00e9nite Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5440-2078","authenticated-orcid":false,"given":"Alessandro","family":"Tomelleri","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Rheumatology Allergy and Rare Diseases (UnIRAR), IRCCS Ospedale San Raffaele & Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5719-8423","authenticated-orcid":false,"given":"Geoffrey","family":"Urbanski","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences School of Dentistry, University of California San Francisco CA USA"},{"name":"Service de M\u00e9decine Interne et Immunologie Clinique, Centre Hospitalier Universitaire Anger Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Vandergheynst","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pitaux Universitaires de Bruxelles, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana","family":"Vieira","sequence":"additional","affiliation":[{"name":"Rheumatology Department Centro Hospitalar de Vila Nova de Gaia e Espinho Vila Nova de Gaia Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Viswanatha","sequence":"additional","affiliation":[{"name":"Division of Hematopathology, Department of Pathology and Laboratory Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wi\u0119sik\u2010Szewczyk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pneumonology, Allergology and Clinical Immunology Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, National Health Institute Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Diral","sequence":"additional","affiliation":[{"name":"Unit of Hematology and Bone Marrow Transplant IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-7336","authenticated-orcid":false,"given":"Benjamin","family":"Terrier","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine interne H\u00f4pital Cochin, Assistance Publique Hopitaux de Paris, Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavisha A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung Blood Institute, National Institute of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fenaux","sequence":"additional","affiliation":[{"name":"Service de H\u00e9matologie H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris, Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8269-9438","authenticated-orcid":false,"given":"Peter C.","family":"Grayson","sequence":"additional","affiliation":[{"name":"Vasculitis Translational Research Program National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-6231","authenticated-orcid":false,"given":"David B.","family":"Beck","sequence":"additional","affiliation":[{"name":"Center for Human Genetics and Genomics, New York University School of Medicine New York NY USA"},{"name":"Division of Rheumatology, Department of Medicine New York University School of Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the International VEXAS working group, and with endorsement of EuroBloodNet, the European Reference Network in Rare Hematological Diseases","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2026834"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.24836"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.03.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20805"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152430"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.1657"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016985"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.05.014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220089"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead506"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae123"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqad186"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004976"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021010811"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000828"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead245"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00375-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3344"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224460"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae201"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-024-00046-z"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010286"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19021"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01857-5"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42471"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010456"},{"issue":"3","key":"e_1_2_6_30_1","first-page":"244","article-title":"Spectrum of clonal hematopoiesis in VEXAS syndrome","volume":"142","author":"Gutierrez\u2010Rodrigues F","year":"2023","journal-title":"Blood"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2021.10.007"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010177"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17893"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01698-8"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2023.103386"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023723"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27169"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01353-8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01031-9"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"issue":"26","key":"e_1_2_6_42_1","first-page":"3591","article-title":"VEXAS syndrome","volume":"137","author":"Grayson PC","year":"2021","journal-title":"Blood"},{"issue":"7","key":"e_1_2_6_43_1","first-page":"ofae405","article-title":"Opportunistic infections, mortality risk, and prevention strategies in patients with vacuoles, E1 enzyme, X\u2010linked, autoinflammatory, somatic (VEXAS) syndrome. Open Forum","volume":"11","author":"Czech M","year":"2024","journal-title":"Infect Dis"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224819"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022329"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2024-225640"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016642"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.129"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05611-w"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02375-3"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012478"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-05942-2"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-024-07160-7"}],"container-title":["Arthritis & Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.43287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/art.43287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.43287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:59:38Z","timestamp":1773712778000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.43287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/art.43287"],"URL":"https:\/\/doi.org\/10.1002\/art.43287","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2024-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}