{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:15:24Z","timestamp":1790810124315,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82361138566"],"award-info":[{"award-number":["82361138566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between the EAT\u2010Lancet diet and rheumatoid arthritis (RA) and the underlying metabolic mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included 205,439 participants who were free of RA at baseline from the UK Biobank. The EAT\u2010Lancet diet index was constructed based on dietary data collected via Oxford WebQ. A metabolomic signature was developed using elastic net regression. The impact of the EAT\u2010Lancet diet index and the metabolomic signature on the risk of incident RA was assessed using Cox proportional hazards models. Causal mediation analysis was performed to assess the mediating effects of the metabolomic signature and metabolites. A genome\u2010wide gene\u2010environment interaction study was conducted to identify genes interacting with the EAT\u2010Lancet diet for RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a mean follow\u2010up of 13 years, 1,897 RA cases were identified. The hazard ratios were 0.93 (95% confidence interval [CI] 0.90\u20130.96) and 0.80 (95% CI 0.70\u20130.93) for 10\u2010point increment of EAT\u2010Lancet diet score and the corresponding metabolomic signature. The metabolomic signature mediated 34.07% (95% CI 21.44%\u201347.00%), primarily through pathways related to inflammation, fatty acids, and fluid balance. Key mediators included glycoprotein acetyls, docosahexaenoic acid, degree of unsaturation, omega\u20103 fatty acids, and albumin. Genes\n                      <jats:italic>B2M<\/jats:italic>\n                      ,\n                      <jats:italic>SLC30A4<\/jats:italic>\n                      ,\n                      <jats:italic>SHF<\/jats:italic>\n                      ,\n                      <jats:italic>SORD<\/jats:italic>\n                      ,\n                      <jats:italic>CASC4<\/jats:italic>\n                      ,\n                      <jats:italic>SPG11<\/jats:italic>\n                      ,\n                      <jats:italic>CRIP2<\/jats:italic>\n                      ,\n                      <jats:italic>BTBD6<\/jats:italic>\n                      , and\n                      <jats:italic>TEX22<\/jats:italic>\n                      were found to interact with the EAT\u2010Lancet diet score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater adherence to the EAT\u2010Lancet diet is linked to a reduced risk of RA, with significant mediation by the metabolomic signature, suggesting the potential of dietary interventions targeting specific metabolic pathways for RA prevention.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/art43297-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  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