{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:40:56Z","timestamp":1769737256782,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1K23AR082955 to Haberman"],"award-info":[{"award-number":["1K23AR082955 to Haberman"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1UC2AR081029 to Scher"],"award-info":[{"award-number":["1UC2AR081029 to Scher"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["3UC2AR081039\u201002S1 toHaberman"],"award-info":[{"award-number":["3UC2AR081039\u201002S1 toHaberman"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["5T32AR069515 to Howe, Scher"],"award-info":[{"award-number":["5T32AR069515 to Howe, Scher"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR084274 to Scher"],"award-info":[{"award-number":["R01AR084274 to Scher"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32\u2010AR\u2010069515 to Haberman, Scher"],"award-info":[{"award-number":["T32\u2010AR\u2010069515 to Haberman, Scher"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","award":["x"],"award-info":[{"award-number":["x"]}],"id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although up to 45% of patients with psoriatic arthritis (PsA) have a family history of psoriatic disease, it is unclear whether this family history contributes to a distinct PsA phenotype and\/or the timing of disease onset. We aimed to identify differences in onset, domain involvement, and disease activity based on family history of psoriatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 843 patients with PsA were enrolled in an observational, longitudinal registry. Demographics, medical history, family history, and psoriatic phenotype and activity were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the total, 379 patients (45.0%) had at least one first\u2010degree relative (FDR) or second\u2010degree relative (SDR) with psoriatic disease. Those with a family history developed psoriasis and PsA earlier than those with no family history (psoriasis: mean 27.6 vs 32.2 years [\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01]; PsA: mean 37.6 years vs 40.3 years [\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01]) and were more likely to have entheseal involvement (36.7% vs 30.0%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). Patients with an FDR or SDR with PsA were diagnosed with psoriasis and PsA earlier than those with an FDR or SDR with psoriasis alone, followed by those with no family history (psoriasis: mean 26.3 vs 27.8 vs 32.2 years, respectively [\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01]; PsA: mean 36.5 vs 37.9 vs 40.3 years, respectively [\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort, patients with PsA with a family history of psoriatic disease were diagnosed with psoriasis and PsA earlier and were more likely to have entheseal involvement compared to those without a family history. Further research incorporating molecular and immune features is needed to investigate genetic, environmental, and epigenetic factors that impact PsA phenotype and severity, as well as the transition from psoriasis to PsA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.43325","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:45:04Z","timestamp":1752486304000},"page":"166-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Familial Aggregation in Psoriatic Arthritis: Phenotypic Differences in Patients With and Without a Family History of Psoriatic Disease"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-4031","authenticated-orcid":false,"given":"Catherine","family":"Howe","sequence":"first","affiliation":[{"name":"New York University Grossman School of Medicine  New 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