{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:28:26Z","timestamp":1792013306890,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Fecal microbiota transplantation (FMT) holds promises as a beneficial supplement to methotrexate in patients with psoriatic arthritis (PsA). We therefore investigated how gut bacterial signatures in patients and donor strain engraftment were associated with long\u2010term response to FMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This exploratory study is based on the FLORA trial cohort, encompassing 31 patients with moderate\u2010to\u2010high PsA disease activity and four FMT donors. Of the 15 patients receiving one single\u2010donor FMT, 13 were included in the per\u2010protocol (PP) population. Stool samples were collected before and after FMT (week 4, 12, and 26). We performed shotgun metagenomics to characterize gut microbiota features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, 17 patients (55%) had a gut microbiota community type dominated by the\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      genus (B\u2010type), whereas 14 (45%) had a\n                      <jats:italic>Prevotella<\/jats:italic>\n                      \u2010driven community type (P\u2010type). The B\u2010 and P\u2010type patients did not differ in disease activity or demographics, but the B\u2010type had a significantly higher species diversity compared to the P\u2010type (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005). In the PP population, five of seven B\u2010type patients versus none of six P\u2010type patients (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.021) achieved a long\u2010term clinical beneficial response at week 26. Bacterial strain richness increased significantly from baseline to week 4 and week 26 in B\u2010type (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.016), but not in P\u2010type, patients. Eighteen engrafted strains persisted only in B\u2010type recipients by week 26, including a\n                      <jats:italic>Bacteroides clarus<\/jats:italic>\n                      strain, which demonstrated a negative effect size regarding arthritis pain and the patients\u2019 global assessment of disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Recipients with a\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      \u2010dominated community structure were more likely to achieve long\u2010term beneficial response following one FMT.\n                    <\/jats:p>\n                  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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kjeldsen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastrointestinal Diseases Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6024-0917","authenticated-orcid":false,"given":"Karsten","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Biomedicine, Department of Biology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-4962","authenticated-orcid":false,"given":"Torkell","family":"Ellingsen","sequence":"additional","affiliation":[{"name":"OUH Frontline Centre for Applied Microbiota and Mucosal Barrier Research (MICARE), Department of Rheumatology, Odense University Hospital and Department of Clinical Research University of Southern Denmark  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